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" Changing the world is not easy, but its pursuit will change you profoundly. "

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" To manipulate the immune system, you need to find the key bottlenecks that govern the system. The T-cell is an absolute bottleneck. "

" An important finding is that by determining the genome sequences of an entire family, one can identify many DNA sequencing errors and thus greatly increase the accuracy of the data. This will ultimately help us understand the role of genetic variations in the diagnosis, treatment, and prevention of disease. "

" If you know the mother's genome and the father's genome, and you see that the children have some genes that neither parent has, then you know that difference is either a mutation or a processing error. "

" If you just focus on the smallest details, you never get the big picture right. "

" The major thing is to view biology as an information science. "

" Medicine will be personalized and preventive: Your genome might predict that you have an 80 percent chance of breast cancer by the time you are 50, but if you take a preventive drug starting when you are 40, the chance will drop to 2 percent. "

" Genes are natural resources. "

" Your genome sequence will become a vital part of your medical record, thereby providing critical information about how to optimize your wellness. "

" Anybody that thought the genome was going to directly provide drugs was a fool. Biological networks are not simple, and making drugs to affect them won't be simple. "

" Life is a process of evolution. "

" The wellness and prevention market will outgrow the health care market. "

" Cloning interferon was not something I wanted to get into. "

" We are evolutionary descendents of this marvellous panoply of life. And what that says unequivocally is we have an utter total obligation to make sure we have an environment that not only is good for us but is good for all living organisms. "

" Data-intensive graph problems abound in the Life Science drug discovery and development process. "

" In the late 1970s, when I was a professor at Caltech, I pioneered four instruments for analyzing genes and proteins that revolutionized modern biology - and one of these, the automated DNA sequencer, enabled the Human Genome Project. "

" Almost never does a single company have excellence in a multiplicity of disciplines. "

" Don't underestimate the power of your vision to change the world. Whether that world is your office, your community, an industry or a global movement, you need to have a core belief that what you contribute can fundamentally change the paradigm or way of thinking about problems. "

" If a startup stays in Microsoft, it does not have a chance, because all it tries to do goes against what Microsoft is about. "

" If you go to the FDA with a drug that's only meant to treat 50 people, and it's a 95 percent cure rate, you'll get your drug approved. "

" The systems approach to biology will be the dominant theme in medicine. "

" The Human Genome Project has given us a genetic parts list. "

" What is unique about humans is their individuality. "

" If you look at healthcare today, it's all about disease. It's not about understanding wellness at all. "

" We don't argue if drug companies create drugs that can cure humans and charge lots of money for them, even though we all have these diseases. It will be pretty hard to make a different argument for genes. "