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" I like to say there's certain things you can't take back: One of them is 'I love you,' and one of them is bullets. "

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" Somebody told me long ago that in acting, it's okay to steal, just steal from the best. "

" I had a Ford F-250. It was a big ol' farm truck, but it wasn't a rig. That's about the biggest I've ever driven. That's what I drove back and forth to high school. I was a poor guy, and it was a truck that my uncle owned and let me drive because I had no money. "

" I don't spend a lot of time online. My mother's really good at picking out if she sees a really great review, and she'll forward it to me. She's like my little Internet filter. It's always nice to see something going up; if I want to find something on Nathan Fillion, I do know where to look, but I've got a nice little delivery system in my mom. "

" I thought what would be really just choice for a revamp and a reboot is 'The Greatest American Hero.' I think I'd be just that kind of perfect not prepared for this kind of thing, but thrust into circumstances he's not prepared for... that's another niche of mine. Unpreparedness. Not knowing what to do. I'm good at being that guy. "

" I think I've been really good at surrounding myself with really talented people. I've picked the right coattails to ride on. "

" I was attending the University of Alberta. I was going to be a high school teacher, like my parents. I failed - no, I didn't fail a class, I just barely passed. I really didn't try. It was Canadian history, through the plays of the time. My God, those were boring plays. "

" I still buy actual books. The smell, having it in your hands - there's really no substitute. "

" I kind of fell backwards into acting. I was studying to be a high school teacher. I look now and I understand completely, or actually barely, how much work it is to be a teacher. It's an incredible amount of work. "

" It's a trap I've fallen into earlier in my career - trying to be liked. Don't do it. When I watch TV and I see someone trying to make me like them, acting cute or quirky or goofy, I'm not impressed. Don't act like America's watching you. Just latch onto your character. Characters are flawed. Be unlikeable. Be flawed. Be a person. "

" I don't expect anybody to know who I am. "

" 'Desperate Housewives' is an ensemble cast, where I played a tertiary character. I made a lot of great friends, but that show didn't keep me very busy. "

" I like doing things where I can get dirty, work with my hands, and use power tools. Last weekend, I did some grouting. "

" Karaoke is something that's near and dear and very close to my heart. I was a karaoke host when I was working my way through university. I was a full-time student and karaoke was my night job. "

" You have a dramatic portion of your television program and you treat it dramatically, and then you have a comedic portion of your program, and you treat it differently. Why do you change who are between the two pieces? You're the same person. Just go. "

" I kind of found a niche for myself after 'Firefly'. I found something that I enjoyed doing and that I did well, but as far as how I seek out a part, it's always different. It's always something that lights you on fire when you read it. It might be just one scene, it might be one line that defines the character for you. "

" I've kind of learned this about Joss Whedon. Never say never. I've learned that. I also have another rule about Joss Whedon. Never say no. Just... whatever Joss Whedon wants to do, just do it. "

" I'm the biggest geek of all. Adventure, fantasy, comic books - I can't get enough. "

" You can't embarrass Joss Whedon, he's got no pride! He fully admits it. 'Oh, it's me. I'm little and goofy.' You can't wound his pride. He's too self-deprecating. "

" You want to put out a TV show? If you have the money to do it on your own, by yourself, and you have a TV network, you can do it by yourself. But the nature of the beast is, art needs finance. That's how this industry works. So until the Internet becomes our source of entertainment - and watch it, I believe it will - this is how things go. "

" Basically, after an ABC sitcom I did, I ended up with a holding deal with 20th Century Fox. Absolutely cool. It pays you to be unemployed. And the bigger the entity that gives you the deal, the better. "

" I'll never look down on and I love running into actors who say 'Oh yeah, I did a soap.' I say 'Tell me which one!' It's like being a member of a secret society. "

" I told myself a while back, 'Love what you do, but don't fall in love with what you do.' That way you won't be brokenhearted if ever it gets canceled five episodes in - which has happened to me. "

" There's comedy even in tragedy. There's comedy in life. And in 'Castle', we go for that comedy. "

" Being in the industry, I've seen many situations where someone will get the call from the network where they say 'You guys have 5 episodes to wrap it up.' Then all your long-term story arcs gotta get wrapped up in five episodes because that's how many episodes you got left. I would hate to see that happen to 'Castle'. "

" It's so great in Hollywood now. You have people past 40 sitting and talking about serious stuff, writing and making movies and TV, but there's laser pistols and superheroes and alien monsters involved. It's viable and mainstream. "

" I consider 'Dr. Horrible' a tremendous success. The fact that it won an Emmy I just think lends validity to what we were doing and the point we were trying to make: taking the power into someone else's hands and changing the world. "

" There are people who have energy that say 'don't come near me, don't get too close.' There's people like Adrienne Shelley who have the energy of 'come over here and give me a hug and if you're around me you're going to be happy about it.' "

" I think TV has been a little bit irresponsible in how they portray these people because homicide detectives are not brooding, tortured souls who are stained with the stink of the city and who have blood on their hands. They are real, live people that are incredibly entertaining. "

" You know, I endeavor to be more like my older brother. He's very magnetic. He's actually very much like 'Castle' in that people are attracted to him, and just want to be near him. You want to know where my brother is in a crowded room? He's the guy with the crowd around him. "

" What I know of Steve Trevor is everything that I learned from 'Wonder Woman,' the television series with Lynda Carter. And I don't remember much. I do remember his uniform, though. "