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" I think that everything I do tends to root for the underdog. "

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" My way of dealing with the world has always been to make fun of it and observe it but not take part in it. That's how I became a writer. But when you have kids, suddenly you have to be part of things. It leads almost to a breakdown because your whole defense mechanism is now really destructive. "

" To me, I've never understood why there is any question about are women as funny as men. "

" There are only so many hilarious actors so when they cross-pollinate, people assume it's always the same actors and directors. "

" I wanted to see how funny I could be without making the choice that every 10 minutes something big and visual had to happen. "

" I'm making a movie about relationships, and I'm surrounded by guys scared of talking to girls. "

" Eventually, the nerds and the geeks will have their day. "

" The thing that is incredibly helpful is that we screen the movies and we ask the audience if they like it or not and we ask a lot of questions and do testing on the movies. For comedies, at least, it's very helpful. If they're not laughing and they don't say that they loved it, then I have screwed up. "

" I put on a big show when I write something I think is funny. "

" I still feel like a nerd. "

" For me, until I know that the audience really gets what I'm trying to communicate I'm not done. "

" I'm the guy who gets uncomfortable. That's why I was able to write 'The 40-Year-Old Virgin' and 'Knocked Up.' I believe in those guys. "

" College is the reward for surviving high school. Most people have great fun stories from college and nightmare stories from high school. "

" I think a lot of Hollywood is in retreat right now trying to figure out how to make money and make the safest bets. "

" I think a lot of studios today are run by women, and we are entering a time when a lot of women have evolved in Second City and Upright Citizens Brigade and wanted to become writers and comedians. "

" I love magazines and film critics, so I eat it up. I'm not one of those people who says 'I never read anything.' I generally read all of it. "

" I've had movies bomb with terrible reviews, I've had movies make a lot of money with terrible reviews, I've had movies get good reviews and make money. And I like it best when the movies do well and the reviewers like them. "

" I always felt as a kid that I was underappreciated, invisible or weird, but I've always secretly thought people would one day appreciate what is different about me. I'm always putting that message out there. "

" I always see other people as predecessors and admire them. "

" It's so difficult to shock America these days. "

" Up until 'Bridesmaids', the general consensus was that women preferred comedy a bit softer. "

" Well, every movie is an experiment. And the only way you can grow at what you're doing is to take chances. You can't try to stick with what worked last time. "

" Television is much more difficult because at every moment the network can force you to change things based on their belief about what would make it popular. You're in a constant debate with a gun at your head, and the gun is cancellation. So it's hard to win the arguments. "

" People like the comedy more when they care about the characters. "

" There was definitely a period when I just felt out of sync with earth. "

" The moment you think of a joke is the best moment. "

" There's something honorable about holding out for love and not breaking up for the sake of the baby. I see people get divorced, and there is a part of me that thinks, I wonder how hard they tried? "

" All of my jokes were about not being able to meet anybody. I didn't have any insight into anything - even my own insecurities. "

" I don't know if you can be a born-again virgin. "