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" In 'Futurama,' the skin color is no longer yellow. They have actually evolved to cartoon skin tone. But they still have four fingers. "

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" I gave away 'Life in Hell' when it was a little 'zine, and sold it at record stores for $1, and I knew from the time that I first did it that I would continue to do it, because it was fun. "

" People go into cartooning because they're shy and they're angry. That's when you're sitting in the back of a classroom drawing the teacher. "

" I don't have to be careful, I've got a gun. "

" I had been drawing my weekly comic strip, 'Life in Hell,' for about five years when I got a call from Jim Brooks, who was developing 'The Tracey Ullman Show' for the brand-new Fox network. He wanted me to come in and pitch an idea for doing little cartoons on that show. "

" I went through a phase where people would introduce me at parties as a cartoonist, and everybody felt sorry for me. 'Oh, Matt's a cartoonist.' Then people further feeling sorry for me would ask me to draw Garfield. Because I'm a cartoonist, draw Snoopy or Garfield or something. "

" We've got a bunch of new writers now who tell me they grew up watching The Simpsons. It's bizarre, and they're writing some very funny stuff. "

" I've conducted an experiment on my kids. Instead of denying them access to media, I've encouraged it. They read comic books, play Nintendo and watch way too much TV. "

" I also found child's play - stuff that was not considered serious, but goofy - was the stuff I liked to do, so I still do it as an adult. "

" I want it to go on, but I want us to go out on top. "

" Our solution on 'The Simpsons' is to do jokes that people who have an education, or some frame of reference, can get. And for the ones who don't, it doesn't matter, because we have Homer banging his head and saying, 'D'oh!' "

" Sometimes people try to read into my strip and find out what my state of mind is. And I can say if I'm in a good mood, generally the comic strip starts out in a good mood, but the punchline is very negative and sour. "

" Because good writing in a TV cartoon is so rare, I think the animation on The Simpsons is often overlooked. "

" Families are about love overcoming emotional torture. "

" Nihilism in American comedy came along way before 'The Simpsons.' There was a fairly nihilistic point of view to 'Saturday Night Live,' for instance, back in the beginning, and a lot of really dark comedy had a really anti-sentimental take on life. "

" I think 'Family Guy' and 'American Dad' have definitely staked out their own style and territory, and now the accusations are coming that 'The Simpsons' is taking jokes from 'Family Guy.' And I can tell you, that ain't the case. "

" A lot of people believe that if everybody just did what they were told - obeyed - everything would be fine. But that's not what life is all about. That's not real. It's never going to happen. "

" I think when 'The Simpsons' first came on, there was an uproar. People got used to it. They realized the show's really funny, it's got a heart, so I think it's pretty safe. "

" As astute followers of 'Life in Hell' will notice, Akbar and Jeff wear the same striped T-shirt as Charlie Brown. 'Peanuts' was very important to me. "

" With Charlie Brown, it was about loneliness and isolation. I always thought that the thing about Charlie Brown and those characters was the absence of the parents. Half the strip was about who wasn't there. The parents were never in the picture. "

" Well, most grown-ups forget what it was like to be a kid. I vowed that I would never forget. "

" It's a funny show. The characters are surprisingly likable, given how ugly they are. We've got this huge cast of characters that we can move around. And over the last few seasons, we've explored some of the secondary characters' personal lives a bit more. "

" Here's to alcohol: the cause of, and answer to, all of life's problems. "

" On 'The Simpsons,' I will say that we definitely like to comment on what's going on in the world, and we try to be funny. If we can figure out a way of being funny about it, then we've gone part of the way of accomplishing our task. "

" We did 'The Simpsons Movie,' which took almost four years; it was the same people that do the TV show, and it just killed us. So that's why there hasn't been a second movie. But I imagine if the show ever does go off the air, they'll start doing movies. "

" Since I was there in the very beginning, I know the history of the characters. So, I make comments about the tone and sometimes remind the writers that we've done that before. "

" A lot of our writers, like Conan O'Brien, moved on to other things. "

" When authorities warn you of the sinfulness of sex, there is an important lesson to be learned. Do not have sex with the authorities. "

" Eat my shorts! "

" You've got to embrace the future. You can whine about it, but you've got to embrace it. "

" Don't have a cow, man. "