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" Most practising scientists focus on 'bite-sized' problems that are timely and tractable. The occupational risk is then to lose sight of the big picture. "

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" Collective human actions are transforming, even ravaging, the biosphere - perhaps irreversibly - through global warming and loss of biodiversity. "

" Space and time may have a structure as intricate as the fauna of a rich ecosystem, but on a scale far larger than the horizon of our observations. "

" We need to broaden our sympathies both in space and time - and perceive ourselves as part of a long heritage, and stewards for an immense future. "

" Science is a part of culture. Indeed, it is the only truly global culture because protons and proteins are the same all over the world, and it's the one culture we can all share. "

" We do not fully understand the consequences of rising populations and increasing energy consumption on the interwoven fabric of atmosphere, water, land and life. "

" We are 'nuclear waste' from the fuel that makes stars shine; indeed, each of us contains atoms whose provenance can be traced back to thousands of different stars spread through our Milky Way. "

" The extreme sophistication of modern technology - wonderful though its benefits are - is, ironically, an impediment to engaging young people with basics: with learning how things work. "

" Issues relating to global health and sustainability must stay high on the agenda if we are to cope with an ageing and ever-increasing population, with growing pressure on resources, and with rising global temperatures. The risks and dangers need to be assessed and then confronted. "

" Crucial to science education is hands-on involvement: showing, not just telling; real experiments and field trips and not just 'virtual reality.' "

" The first voyagers to the stars will be creatures whose life cycle is matched to the voyage: the aeons involved in traversing the galaxy are not daunting to immortal beings. By the end of the third millennium, travel to other stars could be technically feasible. But would there be sufficient motive? "

" In our interconnected world, novel technology could empower just one fanatic, or some weirdo with a mindset of those who now design computer viruses, to trigger some kind of disaster. Indeed, catastrophe could arise simply from technical misadventure - error rather than terror. "

" A monkey is unaware that atoms exist. Likewise, our brainpower may not stretch to the deepest aspects of reality. The bedrock nature of space and time, and the structure of our entire universe, may remain 'open frontiers' beyond human grasp. "

" There's now, for the first time, a huge gulf between the artefacts of our everyday life and what even a single expert, let alone the average child, can comprehend. The gadgets that now pervade young people's lives, iPhones and suchlike, are baffling 'black boxes' - pure magic to most people. "

" Some global hazards are insidious. They stem from pressure on energy supplies, food, water and other natural resources. And they will be aggravated as the population rises to a projected nine billion by mid-century, and by the effects of climate change. An 'ecological shock' could irreversibly degrade our environment. "

" The most important advances, the qualitative leaps, are the least predictable. Not even the best scientists predicted the impact of nuclear physics, and everyday consumer items such as the iPhone would have seemed magic back in the 1950s. "

" We know too little about how life began on Earth to lay confident odds. It may have involved a fluke so rare that it happened only once in the entire galaxy. On the other hand, it may have been almost inevitable, given the right environment. "

" The atmospheric CO2 concentration is rising - mainly due to the burning of fossil fuels. It's agreed that this build-up will, in itself, induce a long-term warming trend, superimposed on all the other complicated effects that make climate fluctuate. "

" In future, children won't perceive the stars as mere twinkling points of light: they'll learn that each is a 'Sun', orbited by planets fully as interesting as those in our Solar system. "

" To ensure continuing prosperity in the global economy, nothing is more important than the development and application of knowledge and skills. "

" When scientists are asked what they are working on, their response is seldom 'Finding the origin of the universe' or 'Seeking to cure cancer.' Usually, they will claim to be tackling a very specific problem - a small piece of the jigsaw that builds up the big picture. "

" The scientists who attack mainstream religion, rather than striving for peaceful coexistence with it, damage science, and also weaken the fight against fundamentalism. "

" Indeed, our everyday world presents intellectual challenges just as daunting as those of the cosmos and the quantum, and that is where 99 per cent of scientists focus their efforts. Even the smallest insect, with its intricate structure, is far more complex than either an atom or a star. "

" Everything, however complicated - breaking waves, migrating birds, and tropical forests - is made of atoms and obeys the equations of quantum physics. But even if those equations could be solved, they wouldn't offer the enlightenment that scientists seek. Each science has its own autonomous concepts and laws. "

" To most people in the U.K., indeed throughout Western Europe, space exploration is primarily perceived as 'what NASA does'. This perception is - in many respects - a valid one. Superpower rivalry during the Cold War ramped up U.S. and Soviet space efforts to a scale that Western Europe had no motive to match. "