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" My philosophy is really based on humility. I don't think we know enough to fix either diagnostics or therapeutics. The future of psychiatry is clinical neuroscience, based on a much deeper understanding of the brain. "

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" For bipolar in adults, I think there's pretty good agreement about what this looks like. For bipolar in children, there is some considerable debate about where are the boundaries. At the mild end, are these just kids who are active? Is this the class clown at the very severe - is this something other than a mood disorder? "

Thomas R. Insel

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" What causes autism? As far as we know in 2013, there is no single gene or single environmental factor that accounts for the more than 1 million Americans with ASDs. "

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" As a scientist leading a funding agency for autism research, I think of autism as a neurodevelopmental disorder. "

" We have to remain humble about our understanding of the brain, because even our most powerful tools remain pretty blunt instruments for decoding the brain. In fact, we still do not know how to decipher the basic language of how the brain works. "

" After a century of studying schizophrenia, the cause of the disorder remains unknown. "

" With the implementation of the Affordable Care Act and the Mental Health Parity and Addiction Equity Act, more people will have insurance coverage and, in principle, be eligible for more care. "

" A National Database on Autism Research is fostering sharing of data and collaborations. Scientists are also making great strides at the interface of biology and engineering with new technologies that are laying the groundwork for future advances. "

" I was sure I was going to be a doctor of global health or tropical medicine in some underdeveloped country. "

" Reports that online cognitive behavioral treatment can be as effective as in-person psychotherapy suggest that technology will expand access, extend the impact of a therapist, and expedite treatment for people who might not find 'seeing' a therapist acceptable. "

" Unlike the heart or kidney, which have a small, defined set of cell types, we still do not have a taxonomy of neurons, and neuroscientists still argue whether specific types of neurons are unique to humans. But there is no disputing that neurons are only about 10 percent of the cells in the human brain. "

" When we talk about the brain, it is anything but unidimensional or simplistic or reductionistic. "

" Most of our brain cells are glial cells, once thought to be mere support cells, but now understood as having a critical role in brain function. Glial cells in the human brain are markedly different from glial cells in other brains, suggesting that they may be important in the evolution of brain function. "

" Neuroscientists talk a lot about brain circuits. In fact, the word 'circuit' is probably misleading. We do not know where most circuits begin and end. And unlike an electrical circuit, brain connections are heavily reciprocal and recursive, so that a direction of information flow can be inferred but sometimes not proven. "

" What do we know about autism in 2013? Autism symptoms generally emerge before age three and usually much earlier, often as language delays or lack of social engagement. Recent research suggests that autism can be detected during the first year of life, even before classic symptoms emerge. Indeed, the symptoms may be a late stage of autism. "

" From wearable sensors to video game treatments, everyone seems to be looking to technology as the next wave of innovation for mental health care. "

" We need to ask whether, in the long term, some individuals with a history of psychosis may do better off medication. "

" Sometimes, patients with serious mental illness, just as with other serious medical illnesses, require hospitalization. In the absence of available public or private hospital beds, there are few options. "

" The good-news stories in medicine are early detection, early intervention. "

" Nearly every business collects metrics on inventory, sales, and workplace process. Health care has been slow to measure these kinds of outcomes. Increasingly, general medicine, via either managed care or large practice settings, is improving by collecting data through electronic records and refining practice based on what works. "

" I trained in psychiatry in the 1970s, and much of our training was about what was then psychoanalytic theory, with a little bit of theory from Jungian psychology and a few other places. "