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" The technologies which have had the most profound effects on human life are usually simple. "

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" The marketplace judges technologies by their practical effectiveness, by whether they succeed or fail to do the job they are designed to do. "

" If you start out with a tragic view of life, then anything since is just a bonus. "

" I'm a mathematician, basically. What I do is look around for problems where I can find useful applications for mathematics. All I do, really, is the math, and other people have the ideas. "

" Biology is now bigger than physics, as measured by the size of budgets, by the size of the workforce, or by the output of major discoveries; and biology is likely to remain the biggest part of science through the twenty-first century. "

" Scepticism is as important for a good journalist as it is for a good scientist. "

" You ask: what is the meaning or purpose of life? I can only answer with another question: do you think we are wise enough to read God's mind? "

" The biologists have essentially been pushed aside. Al Gore's just an opportunist. The person who is really responsible for this overestimate of global warming is Jim Hansen. He consistently exaggerates all the dangers. "

" I like people who are working on practical things and who are working in teams. It's not so important to get the glory. It's much more important to get something that works. It's a better way to live. "

" I don't believe in technological determinism, especially not in biology and medicine. We have strong laws to keep doctors from monkeying around with humans that will remain in place. It's simply not true that everything that is technologically possible gets done. "

" The technologies that raise the fewest ethical problems are those that work on a human scale, brightening the lives of individual people. "

" There is a great satisfaction in building good tools for other people to use. "

" What the world needs is a small, compact, flexible fusion technology that could make electricity where and when it is needed. The existing fusion program is leading to a huge source of centralized power, at a price that nobody except a government can afford. "

" The PhD system is the real root of the evil of academic snobbery. People who have PhDs consider themselves a priesthood, and inventors generally don't have PhDs. "

" The question that will decide our destiny is not whether we shall expand into space. It is: shall we be one species or a million? A million species will not exhaust the ecological niches that are awaiting the arrival of intelligence. "

" The fact that the climate is getting warmer doesn't scare me at all. There's no reason why one should be scared. "

" Successful technologies often begin as hobbies. Jacques Cousteau invented scuba diving because he enjoyed exploring caves. The Wright brothers invented flying as a relief from the monotony of their normal business of selling and repairing bicycles. "

" It's better to get mugged than to live a life of fear. "

" It's as great a part of the human adventure to invent things as to understand them. John Randall wasn't a great scientist, but he was a great inventor. There's been lots more like him, and it's a shame they don't get Nobel Prizes. "

" The important thing is that we now have the tools to sequence all kinds of animals and plants and microbes - as well as humans. It is not important that we didn't actually finish the human sequence yet. "

" Younger people have so many opportunities. I don't see any pessimism among them. "

" The pain of childbirth is not remembered. It's the child that's remembered. "

" I have the freedom to do what I want... bright people to talk to every day. "

" A good scientist is a person with original ideas. A good engineer is a person who makes a design that works with as few original ideas as possible. There are no prima donnas in engineering. "

" I don't think of myself predicting things. I'm expressing possibilities. Things that could happen. To a large extent it's a question of how badly people want them to. "

" Lucky individuals in each generation find technology appropriate to their needs. "

" It has become part of the accepted wisdom to say that the twentieth century was the century of physics and the twenty-first century will be the century of biology. "

" The climate-studies people who work with models always tend to overestimate their models. They come to believe models are real and forget they are only models. "

" We have no reason to think that climate change is harmful if you look at the world as a whole. Most places, in fact, are better off being warmer than being colder. And historically, the really bad times for the environment and for people have been the cold periods rather than the warm periods. "

" Every orchid or rose or lizard or snake is the work of a dedicated and skilled breeder. There are thousands of people, amateurs and professionals, who devote their lives to this business. Now imagine what will happen when the tools of genetic engineering become accessible to these people. "

" Just because you see pictures of glaciers falling into the ocean doesn't mean anything bad is happening. This is something that happens all the time. It's part of the natural cycle of things. We know from measurements that glaciers have been melting for 200 years at least. "