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" There's always something that an engineer can do to make microscopes better. "

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" The question was, 'Is there a way of minimizing the amount of damage you're doing so that you can then study cells in a physiological manner while also studying them at high spatial and temporal resolution for a long time?' "

" Every new invention is like a baby. You think it may cure cancer or become the president, but in the end, you're happy it just stays out of jail. "

" What was shocking to us was that by spreading the energy out across seven beams instead of one, the phototoxicity went way down. "

" It takes a huge amount of effort to move from a successful high-tech prototype to broader adoption of an imaging technology. "

" Sometimes I make an analogy that each scientific paper is like putting out another record. And some people have careers that are nothing but a one-hit wonder. And then there are people who are only appreciated by aficionados but largely forgotten by the wider community. "

" In essence, we're imaging the same cell for anywhere from forty to a hundred thousand times to create one of the movies that we see. "

" I'm spoiled. All of my adult jobs have left me with complete freedom to come up with what I wanted. "

" It's nice to be able to look at one protein, but life is driven by the interactions between proteins, so it's really essential to be able to see multiple proteins at a time to understand these interactions. "

" I was born in 1960 and can still tell you the name of every astronaut from Mercury to Apollo. If I had a chance, I'd love to go into space on one of the privately developed space crafts. "

" In my opinion, the only real asset one has is one's reputation, right? I mean, any company and institution can go belly up at any time. But if you have a good reputation, you know, you can usually find somebody who can - who thinks they can use what you have to offer. "

" I really didn't like the academic structure of science, but I realized I loved science and missed science. "

" Frankly, I guess, I don't really understand why people, why so many people, are so risk averse. You know, there's always ways to wiggle your way out of any situation if you're motivated enough. "

" Honestly, I feel you are poisoned if you read too much of the scientific literature because it makes you start thinking like other people. You're better off having a vague sense of what's going on and making your own way. "

" Science goes through fads, and there are big ups and crashes. "

" I missed the basic curiosity of being in the lab. "

" Like you can't have a car that can take the kids to schools on Friday and win the grand prix on Saturday, you can't make a microscope that can do it all. "

" There are many cells you could look at forever in 3D. "

" One thing I liked about being in microscopy is it gets you out of your box constantly because there's such a diverse range of applications. "

" I don't like saying 'no' to people, and I'm going to have to learn how to say 'no' more. "

" Chemistry was always my weakest subject in high school and college. "

" When I listen to music from different eras, I sense different things. The 1940s music, there's so much optimism and romance, maybe because they just solved the biggest problem on Earth at that time - World War II. In the 1960s, there was so much creativity and innovation in sound. "

" You need a continuous picture of how things are evolving, and not a slow series of snapshots where you don't know how frame A is related to frame B. "

" The eventual goal is to marry all of my work together to make a high-speed, high-resolution, low-impact tool that can look deep inside biological systems. "

" It always irritated me that people think they have to be locked into a career path. "

" I hate driving a bandwagon. "

" You get so tied up with the minutiae of the day-to-day, there's never a chance to sit back and let your subconscious run wild. "