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" When high school students ask to spend their afternoons and weekends in my laboratory, I am amazed: I didn't develop that kind of enthusiasm for science until I was 28 years old. "

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" I'm used to being surrounded by really smart 22-year-old students who have no problem saying that something I suggested is not a very good idea. "

Harold E. Varmus

Good

Students

Smart

" Just after graduation in 1966, like many of my contemporaries, I applied for research training at the National Institutes of Health. Perhaps because his wife was a poet, Ira Pastan agreed to take me into his laboratory, despite my lack of scientific credentials. "

Harold E. Varmus

Research

Wife

" All basic scientists who look to the NCI for funding should know that I will tolerate no retreat on the study of model systems and the pursuit of fundamental biological principles. "

" The NCI scientific programme leaders meet regularly to ensure that we are not ignoring highly original proposals and that we are not creating an unbalanced grant portfolio. "

" As an undergraduate at Amherst College, I was devoted to Dickensian novels and antiestablishment journalism while marginally fulfilling premedical requirements. "

" When I was the NIH director, I often expressed envy of institute directors: they had the money and ran the scientific programmes. "

" I had learned of Gertrude Stein's bon mot that medicine opened all doors. This prompted me, in different moods, to view my future life as literary psychiatrist, globe-trotting tropical disease specialist, or academic internist. "

Harold E. Varmus

Life

View

" Our biggest single theme is trying to make the NIH work better with the same amount of money. "

" I begin with the premise that behavior is an incredibly important element in medicine. People's habits, their willingness to quit smoking, their willingness to take steps to avoid transmission of HIV, are all behavioral questions. "

" Cancer is a collection of many diseases with common principles, and each disease will have to be understood and more effectively controlled on its own terms. "

Harold E. Varmus

Principles

Cancer

" I believe that we are going to have a much deeper appreciation of what kinds of abnormalities in cancer cells and in the surrounding cells that feed and respond to cancers are vulnerabilities that will allow us to make better predictions of which kinds of drugs will work to treat these cancers. "

" In the 1960s and '70s, there wasn't much evidence at all. We knew vaguely the causes of cancer, but methods like genomics were very new. "

" From some dilatory reading in the early 1960s, I knew enough about viruses and their association with tumors in animals to understand that they might provide a relatively simple entry into a problem as complex as cancer. "

" A major feature of life at the NIH in late 1960s was the extraordinary offering of evening courses for physicians attempting to become scientists as they neared thirty. "

" I had learned that science is a rewarding, active process of discovery, not the passive absorption of what others had discovered. "

" In preparation for a career in academic medicine, I worked as a medical house officer at Columbia-Presbyterian Hospital from 1966 to 1968 and then joined Ira Pastan's laboratory at the National Institutes of Health as a Clinical Associate. "

" Science can improve lives in ways that are elegant in design and moving in practice. "

" When I read about genetics, I see breakthroughs every day. And while I'm trying to learn more about behavioral science, I must say that I don't feel I get tremendous intellectual stimulation from most of the things I read. "

" In general, all cancers have been traditionally characterized by the way they appear under the microscope and the organs in which they arise. "

" I keep encouraging the pharmaceutical companies to put more money into R&D. "

" I was born in the shadow of World War II, on December 18, 1939, on the South Shore of Long Island, a product of the early -wentieth-century emigration of Eastern European Jewry to New York City and its environs. "

" Tobacco, UV rays, viruses, heredity, and age are the main causes of cancer. "

" Every cancer looks different. Every cancer has similarities to other cancers. And we're trying to milk those differences and similarities to do a better job of predicting how things are going to work out and making new drugs. "

" Some growths can be detected early, making for increased accuracy in diagnosis. Some can be cured and others controlled. "

" Anyone graduating from medical school in 1966 had first to fulfill military service before launching a career. Fiercely opposed to the Vietnam War, I sought to avoid it through an assignment to the Public Health Service. "

" Following graduation from Amherst, a Woodrow Wilson Fellowship enabled me to test the depth of my interest in literary scholarship by beginning graduate studies at Harvard University. "

Harold E. Varmus

Test

Harvard

" The public schools I attended were dominated by athletics and rarely inspiring intellectually, but I enjoyed a small circle of interesting friends despite my ineptitude at team sports and my preference for reading. "

" I saw my friends in medical school seeming to be more engaged with the real world. That provoked a sort of jealousy, and I decided to go to medical school after all. "