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" Applying smarter IT to genomic data may offer the potential to cure many types of cancer and other diseases. "

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" I'm always investing and building things at the same time. "

" Innovative cultures transparently document spending, admit mistakes, and ask how they can do better. "

" Technological unemployment is scary for those affected - but has always gone hand in hand with economic progress. "

" Good government is one of the most important factors in economic growth and social well-being. "

" Success gives you a platform for further success - suddenly everybody wants to work with you, and your opportunities and possibilities open up. But at the same time, success is also immensely challenging - it ultimately often creates pride, stubbornness, and sloppiness that beget failure, taking down people and organizations. "

" Being a great founder or early team member is a difficult dialectic - you have to be a bit overconfident, and a big ego isn't always a bad thing. To change the world requires pushing really, really hard and believing you and your team know something others don't. "

Change The World

" The reason we have so much talent in Silicon Valley building and investing in for-profit technology companies is that markets richly reward successful ideas, no matter who invents them. But to remain competitive in a free market, companies must exercise discipline to meet quantitative goals and eventually become cashflow positive. "

" Fear is the wrong response to technological unemployment. Focusing on economic flexibility and adaptability - with special attention to eliminating the barriers we've accidentally created to the mobility of the working classes - is the right response to technological disruption. "

" Those who serve in our armed forces do so from a profound sense of duty to secure liberty for their fellow Americans. They enlist to serve their fellow citizens who express their will through elected representatives, not an unaccountable defense establishment. "

" Our family is very, very competitive. But it's a fun and inspiring sort of competitive. It makes you proud of what you do and makes you want to work hard and do all your homework so you can win. "

" For me, seed investing isn't just a good return area but a big part of how we network in Silicon Valley. A lot of our best deals have come from being active in the seed stage. "

" Hard work enables us to improve ourselves and the world around us, to combat injustice, reduce suffering, and increase human freedom. "

" In my experience, it's common that deep truths exist at both extremes of a dialectic, and the wisest stance on an issue will incorporate 'both of the opposites within itself.' "

" There are people who are better managers than I am. I aspire to be a really good manager, but it's not my natural personality to do the same thing for 14 hours a day. I have a lot of different interests. I really like product and strategy and business strategy, and I think I'm not bad at it. "

" One of the most important jobs of a great leader is to attract great talent. "

" A policy of knowing your replacement is one of the best ways to drive a growth culture. It anticipates and eliminates the most harmful politics in leadership for an expanding company and instantly sets the right tone for a high-talent, growth-mindset executive team. "

" Great leaders inspire incredible loyalty in their followers and subordinates. "

" Entrepreneurship is, in large part, about building something from nothing, which means creating a cause. "

" America faces a mounting transportation crisis, and the primary culprit is road congestion. Traffic makes us unhealthy, wastes enormous amounts of time, and cripples national productivity. America needs expanded roads and transportation infrastructure, but traditional gas tax funding is no longer available. "

" A true leader must strive towards a grand vision of human progress, but remember that the minor details of her everyday life really matter to those who look up to her as a role model. "

" The human mind and body remains the most complex, powerful machine on the planet, and we will adapt and thrive in a world of accelerating technological change. "

" Wealth is only ever actually created from the bottom-up, with free people employing their distinctly human creativity and finding ways to serve and employ others. "

" Marketing is your battle plan for the sales team - it's about defining the landscape. Marketing is doing cohort analysis and understanding exactly what possible customers are out there. It's understanding not only which customers will respond to what messages, but also how customers will become clients if you include certain product features. "

" Palantir owes much of its success to the amazing talent of the first 30-40 technologists who joined the company, as well as to the internal leadership that helped motivate this core group to achieve its ambitious goals and to continue to attract extraordinary people. "