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" By the time Florence Nightingale got her neurotic hands on Cleopatra, she had been mangled beyond recognition by both history and literature. "

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" Life-writing calls for any number of dubious gifts: A touch of O.C.D., a lack of imagination, a large desk, neutrality of Swiss proportions, tactlessness, a high tolerance for archival dust. Most of all it calls for an act of displacement. 'To find your subject, you must in some sense lose yourself along the way,' is Richard Holmes's version. "

" In 'Plutarch,' her voice begins to come out; there are actual 2,000-year-old quotes from Cleopatra, and they are sly and saucy. "

" The desk thing is a problem for me. The ideal one would be vast and perfectly clear. Yet the bane of the biographical existence is paper; if you're 'an artist under oath' you're writing from a mountain of documentation. "

" Reality does not easily give up meaning; it's the biographer's job to clobber it into submission. You're meant not only to tame it but to extract substance, to identify cause and axiomatic effect. You subsist on the tactical omissions, the hollow words, the oddly unconnected dots. "

" No one in the modern world controls the wealth or territory that Cleopatra did. "

" From every ancient source, we have testimony to Cleopatra's irresistible charm, as Plutarch has it, to her ability to speak many languages including, as he puts it, the language of flattery and essentially, to be able to turn people to her will - really a great political genius, in that respect. "

" The interesting thing about Cleopatra is that she is such a shape-shifter. I mean through history we've all molded her to our times and our places. So there's room for a movie for her, but I don't think it will hew to the book. "

" Here you have an incredibly ambitious, accomplished woman who comes up against some of the same problems that women in power come up against today. Cleopatra plays an oddly pivotal role in world history as well; in her lifetime, Alexandria is the center of the universe, Rome is still a backwater. "

" Certainly, I am writing as a 21st-century woman, so I am much more inclined to view her as a three-dimensional woman. I think we keep coming up with this stubborn problem of a woman being judged by her appearance rather than her accomplishments. We are much more inclined to ask: was Cleopatra beautiful? "

" Cleopatra was on a political mission to save her country and her power, but what we remember about her are these two famed seductions, which are a matter of politics, not a matter of love. "

" Nonfiction writers are the packhorses of literature. We're meant to carry the story. If we can make it up and down the mountain by a reliable if not scenic route, we have delivered. Technique is optional. "

" We're talking about, essentially, the Roman historians, who wrote Cleopatra into the story mostly so that they could talk about the rise of Rome. And that is one of the problems, of course, in recounting her life. She's only ever apparent to us when there is a Roman in the room, or when her story intersects with the rise of Rome. "

" Women enjoyed rights in Egypt they would not again enjoy for more than 2,000 years. They owned ships, ran vineyards, filed lawsuits, practiced medicine. Their husbands supported them after divorce. Their power was unprecedented. "

" For thousands of years, men have written history, so it seems to me that most of what we've read is from the male point of view. "

" You ever try to leave New York? I did once. I lasted about a year. "

" I don't think there is ever objective biography. Our vision of our subject is always shaped by who we are. So I do, of course, think the biographer's view is always something to keep in mind. "

" The biographer has two lives: The one she leads, and the one she ultimately understands. "

" Strangely enough, politics may just be the one realm in which having kids imposes no penalty on women. Kids are practically a necessity. For scientists, or Supreme Court justices, or chief executives, or the woman who wants to learn to fly F-l8s off an aircraft carrier, it works differently. "

" I have three children, each of whom is having an idyllic childhood, probably because I have been at the office the entire time. "

" A woman can never be too rich or too thin, but until very, very recently, she could be too powerful, for which - if she wasn't smart enough to camouflage herself - she generally paid the price. "

" Of course, women have long exercised influence behind the scenes. A few thousand years ago this drove Aristotle to distraction: 'What difference does it make whether women rule or the rulers are ruled by women? The result is the same.' "

" What we know about Cleopatra's looks is based purely on her coin portraits. Engraving was imperfect, and that when you are a ruler and you ask for a coin to be engraved with your likeness on it, you are probably trying to project a certain air of authority. "

" No biographical subject is ever on hold with the orthodontist. If there's a dry spell, it's your job to curtail or eliminate it. "

" We don't know how Cleopatra spent her days, but we do know how other Hellenistic monarchs spent their days. There has been a great amount of scholarship in the last 30 years about education in the Hellenistic world and women in the Hellenistic world. We now know how an upper-class woman was educated in her day. "

" For a few thousand years, women had no history. Marriage was our calling, and meekness our virtue. Over the last century, in stuttering succession, we have gained a voice, a vote, a room, a playing field of our own. Decorously or defiantly, we now approach what surely qualifies as the final frontier. "

" I think with every book you realize you are partway through and there is something really elementary that you should have researched. "

" Have you ever been married? Had that thing of someone calling you by a name not your own? It's unsettling. It's like a fictitious person. "

" Recently a study proved that working from a larger, less cluttered computer screen increases concentration. I could have told them that. And yes, I write first drafts with a mechanical pencil and a yellow legal pad. There's good reason for this primitive behavior: I am a crackerjack typist. My hand moves far more quickly than my brain. "

" I went out to the desert where Cleopatra camped out with her mercenary army. It's a desolate outpost. Nothing has changed since her day. You realize how far she had to travel. Not only is it a good 150 miles against the current, you can't take a ship. "

" When finally I mustered the courage to tell a novelist friend that I was talking to editors about a biography, her reply was, 'Oh, that's okay. That's not a real book.' "