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" If we think of the immune system as a machine, then we are far from even knowing all of its parts. "

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" Autoimmunity is probably the next frontier. The majority of cases of autoimmune disease result from a complex genetic problem that has environmental influences. It is a colossal task for the immune system to maintain tolerance to self and yet be ready to react to everything in the world around us. "

" A mutation can create an alternative form of a phenomenon - a phenotype or trait - and we can learn a lot by seeing this alternative state. Once I saw a mouse with no eyelids. It simply had a membrane over the eyes. I found it fascinating that there is a single gene required for eyelids to develop. "

" I grew up hoping that my father might win a Nobel Prize. "

" Science is far from the center of the world for most people: even for many with highly sophisticated tastes, interests, and accomplishments. "

" I felt I ought not to be wasting time, and I hurried to graduate from high school to enroll at UCSD. I also hurried to finish college, to go on to higher studies. By the time I was in my teens, I had a strong sense of mission, wanting to discover something important or solve a major problem in biology or medicine. "

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