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" My idea right from the beginning, I guess, was to dismantle the immune system one gene at a time so we could track the mutations that cause problems. "

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" A mutation can create an alternative form of a phenomenon - a phenotype or trait - and we can learn a lot by seeing this alternative state. Once I saw a mouse with no eyelids. It simply had a membrane over the eyes. I found it fascinating that there is a single gene required for eyelids to develop. "

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