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" The origin of life is one of the great outstanding mysteries of science. "

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" It is possible that a scientific discovery will be made that humans will later regret because it has awful consequences. The problem is, we probably would not know in advance and, once the discovery is made, it cannot be undiscovered. "

" In science, a healthy skepticism is a professional necessity, whereas in religion, having belief without evidence is regarded as a virtue. "

" Science, we are repeatedly told, is the most reliable form of knowledge about the world because it is based on testable hypotheses. Religion, by contrast, is based on faith. The term 'doubting Thomas' well illustrates the difference. "

" When I was a student, the laws of physics were regarded as completely off limits. The job of the scientist, we were told, is to discover the laws and apply them, not inquire into their provenance. "

" My feeling is that scientific method has the power to account for and interlink all phenomena in the universe, including its origin, using the laws of nature. But that still leaves the laws unexplained. "

" The birth of science as we know it arguably began with Isaac Newton's formulation of the laws of gravitation and motion. It is no exaggeration to say that physics was reborn in the early 20th-century with the twin revolutions of quantum mechanics and the theory of relativity. "

" The vast majority of terrestrial species are in fact microbes, and scientists have only begun scratching the surface of the microbial realm. It is entirely possible that examples of life as we don't know it have so far been overlooked. "

" The way life manages information involves a logical structure that differs fundamentally from mere complex chemistry. Therefore chemistry alone will not explain life's origin, any more than a study of silicon, copper and plastic will explain how a computer can execute a program. "

" A universe that came from nothing in the big bang will disappear into nothing at the big crunch. Its glorious few zillion years of existence not even a memory. "

" Astonishingly, in spite of decades of research, there is no agreed theory of cancer, no explanation for why, inside almost all healthy cells, there lurks a highly efficient cancer subroutine that can be activated by a variety of agents - radiation, chemicals, inflammation and infection. "

" Should we find a second form of life right here on our doorstep, we could be confident that life is a truly cosmic phenomenon. If so, there may well be sentient beings somewhere in the galaxy wondering, as do we, if they are not alone in the universe. "

" Astronauts have been stuck in low-Earth orbit, boldly going nowhere. American attempts to kick-start a new phase of lunar exploration have stalled amid the realisation that NASA's budget is too small for the job. "

" The language of chemistry simply does not mesh with that of biology. Chemistry is about substances and how they react, whereas biology appeals to concepts such as information and organisation. Informational narratives permeate biology. "

" Scientists have no agreed theory of the origin of life - plenty of scenarios, conjectures and just-so stories, but nothing with solid experimental support. "

" Most research into life's murky origin has been carried out by chemists. They've tried a variety of approaches in their attempts to recreate the first steps on the road to life, but little progress has been made. Perhaps that is no surprise, given life's stupendous complexity. "

" Cancer is such a ruthless adversary because it behaves as if it has its own fiendishly cunning agenda. "

" If we do discover more than one type of life on Earth, we can be fairly certain that the universe is teeming with it, for it would be inconceivable that life started twice here but never on all the other earth-like planets. "

" No planet is more earth-like than Earth itself, so if life really does pop up readily in earth-like conditions, then surely it should have arisen many times right here on our home planet? And how do we know it didn't? The truth is, nobody has looked. "

" For me, science is already fantastical enough. Unlocking the secrets of nature with fundamental physics or cosmology or astrobiology leads you into a wonderland compared with which beliefs in things like alien abductions pale into insignificance. "

" A permanent base on Mars would have a number of advantages beyond being a bonanza for planetary science and geology. If, as some evidence suggests, exotic micro-organisms have arisen independently of terrestrial life, studying them could revolutionise biology, medicine and biotechnology. "

" Is there anything science should not try to explain? Science is knowledge and knowledge is power - power to do good or evil. Sometimes ignorance is bliss. "

" In the frantic search for an elusive 'cure,' few researchers stand back and ask a very basic question: why does cancer exist? What is its place in the grand story of life? "

" Cancer cells come pre-programmed to execute a well-defined cascade of changes, seemingly designed to facilitate both their enhanced survival and their dissemination through the bloodstream. There is even an air of conspiracy in the way that tumours use chemical signals to create cancer-friendly niches in remote organs. "

" Clearly, some creative thinking is badly needed if humans are to have a future beyond Earth. Returning to the Moon may be worthy and attainable, but it fails to capture the public's imagination. What does get people excited is the prospect of a mission to Mars. "