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" There is a very moving and ancient connection between cancer and depression. "
Siddhartha Mukherjee
Depression
Moving
Cancer
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" Good physicians are rarely dispassionate. They agonize and self-doubt over patients. "
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" It turns out that the very genes that turn on in cancer cells perform vital functions in normal cells. In other words, the very genes that allow our embryos to grow or our brains to grow, our bodies to grow, if you mutate them, if you distort them, then you unleash cancer. "
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" The history is important because science is a discipline deeply immersed in history. In other words, every time you perform an experiment in science or in medicine, what you're actually doing is you're answering someone, answering a question raised by someone in the past. "
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" If you take 100 breast-cancer samples, 100 types of cancer have 100 different hallmarks of mutated genes. You could be nihilistic and say, 'Oh, God, we'll never be able to tackle this!' But there are deep, systematic, organizational principles at work in all that diversity. "
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" I'm human, we all are - all doctors are - and grieving is a natural part of medicine. As a doctor, grieving is a natural part of medicine. If you deny that, again, you'd get into this trap of curing and victory. I think grief is very important. "
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" We may have to learn to live with cancer rather than die of it. It means a big change in our mindset and how we do research. We haven't quite reached there yet. "
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" I am a scientist and I am a physician. So I write papers. "
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" If something is good, more is not necessarily better. Not always. "
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" Sidney Farber was a pathologist. He was called a doctor of the dead. He was a pathologist who sort of lived in the basement of the children's hospital in Boston, and he became very interested in childhood leukemia. And Farber began to inject this drug, aminopterin, into young kids, in order to see if he could get a remission. "
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" I once set myself a deadline: half a chapter a week, 20 minutes a day. The thought froze me instantly, like literary Botox. I returned to my non-schedule: sleeping, writing 20 minutes, and then back to sleep. Breakfast in bed, with juice congealing on the sill: pages and pages began to pour out again. "
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Breakfast
" Mary Lasker was an entrepreneur; she was a socialite. She was kind of a legendary networker. She became interested in saying, 'Well, you know, if these diseases don't have political support we'll never conquer them.' And she made, really, cancer her special cause. "
Siddhartha Mukherjee
Saying
Political
Conquer
" Because I work on leukemia, the image of cancer I carry in my mind is that of blood. I imagine that doctors who work on breast cancer or pancreatic cancer have very different visualizations. "
Siddhartha Mukherjee
Blood
Work
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" In a spiritual sense, a positive attitude may help you get through chemotherapy and surgery and radiation and what have you. But a positive mental attitude does not cure cancer - any more than a negative mental attitude causes cancer. "
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" There is an enormous amount of options that a physician can provide today, right down from curing patients, treating patients, or providing patients with psychic solace or pain relief. So, in fact, the gamut of medical intervention is enormous. "
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" Cell culture is a little like gardening. You sit and you look at cells, and then you see something and say, 'You know, that doesn't look right'. "
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" Science is among the most profoundly human of our activities. Far from being subsumed by the dehumanising effects of technology, science, in fact, remains our last stand against it. "
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" Most days, I go home and I feel rejuvenated. I feel ebullient. "
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" Writing anything as an expert is really poisonous to the writing process, because you lose the quality of discovery. "
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" Why did I write 'The Emperor of All Maladies?' A 56-year-old woman with an abdominal sarcoma, having undergone two remissions and a relapse, asked me to describe what she was battling. By the time I had finished answering her, I realised that I had written 600 pages. "
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" Cancer is not one disease but many diseases. "
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" Robert Sandler is a child who died when he was three years old, and he is a child who was the first child that we know of to be treated with chemotherapy. "
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" My memory of my household is of one immersed in books and music. I have a very intimate relationship with Bengali literature, particularly Tagore, and my interest besides reading then was music. "
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Memory
Relationship
Reading
" I think you would have to be a nihilist to say that we are not making progress on cancer, just like you'd have to be hubristically optimistic to say that we have conquered cancer. "
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Say
Progress
" There's a phrase in Shakespeare: he refers to it as the 'hidden imposthume', and this idea of a hidden swelling is seminal to cancer. But even in more contemporary writing it's called 'the big C'. "
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Hidden
Writing
" One day, I had a patient who was going through chemotherapy who came to me and said, 'I'm going to go on with what I'm doing, but I need you to tell me what it is that I'm fighting.' "
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" Cancer is not just a dividing cell. It's a complex disease: It invades, it metastasizes, it evades the immune system. "
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" A strong intuition is much more powerful than a weal test. Normals teach us rules; outliers teach us laws. For every perfect medical experiment, there is a perfect human bias. "
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" When you immerse yourself in medicine you realise that hope is not absolute. It's not that simple. "
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" I think when we use 'stress', we are often using a kind of dummy word to try to fit many different things into one big category. "
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" We don't know why, but pancreatic cancer has a very interesting physiological link to depression. There seems to be a deep link, and we don't know what it is. "
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