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" There seems little reason to prescribe anti-depressant medication to any but the most severely depressed patients. "

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" There are a variety of techniques to help people change the kind of thinking that leads them to become depressed. These techniques are called cognitive behavioral therapy. "

" Perhaps anti-depressants should be best reserved for the very extreme cases and, more importantly, for those who do not respond to alternative forms of interventions. "

" Psychotherapy works, and some types of therapy have been shown to be much more effective than antidepressants over the long run. "

" Antidepressants can have troubling side effects and are addictive for some people. "

" I do a lot of research on the placebo effect, not just in depression but in irritable bowel syndrome, pain, arthritis of the knee, migraine, asthma. "

" Depression comes back over time in about 90 percent of people on antidepressants. Studies show that relapses are far less common when people are treated with psychotherapy. "

" The doctor-patient relationship is critical to the placebo effect. "

" One problem I have with drug companies is that they don't make all their data public. "

" If doctors just spent more time with their patients so they felt more reassured, that might help. "

" Anything that instills a sense of hope will at least temporarily help treat depression. "

" Nocebos often cause a physical effect, but it's not a physically produced effect. What's the cause? In many cases, it's an unanswered question. "

" The one thing we do know is that the chemical imbalance theory - the theory that people get depressed when they don't have enough serotonin in their brain - we know that that's wrong. "

" The big bulk of the response to antidepressants is the placebo response. "

" Patients who trust their doctors and have a psychological expectation of getting better could trigger a reaction in their body. "

" Perhaps 10 percent of patients who are prescribed antidepressants are really benefiting from the drugs' active ingredients. "

" To someone who is not currently on anti-depressants, I would suggest trying other treatments first - for example, psychotherapy. "

" There seem to be many causes of depression. One cause is profound loss, grief. Economic hardship we know is linked to depression. We don't have a full picture. "