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" I am a coffee fanatic. Once you go to proper coffee, you can't go back. You cannot go back. "

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" I really do believe the camera steals the soul. But that may be because I'm worried about my soul. I don't have much of a soul to begin with; I can't afford to lose much. "

" The great trap for non-American actors trying to play Americans, I think, is to start thinking of American-ness as a characteristic. It isn't. It is no more a character trait than height. It is just a physical fact, and that's all there is to it. "

" I don't talk like House, or walk like him. I certainly don't think like him. I don't like to think for more than 15 minutes at a stretch actually; I am a fragile flower. "

" I think maybe even one of the reasons I became an actor was actually to hide. I mean, it sounds paradoxical because, of course, people are standing up in a public place and encouraging other people to look at them. So that's not the conventional definition of hiding. "

" Believe it or not, perhaps I don't show it much, or well, but I think I like people. "

" I think actors are attracted to the idea of other identities and concealing themselves behind some other identity. "

" I have always stuck up for Western medicine. You can chew all the celery you want, but without antibiotics, three quarters of us would not be here. "

" I was too shy, I think, to sing publicly. It takes a particular kind of person. And when I was young, I was not that person. In the first instance, when a record company said to me, do you want to try and make your record, my first reaction was, no, I'm not worthy - I couldn't possibly, and so on and so forth. "

" I never was someone who was at ease with happiness. "

" Piano was - well, all musical instruments were taught in this very rigid, formal, classical method when I was young. "

" The first big stars, Bessie Smith, Ma Rainey, you know, these were gigantic stars. I even wonder sometimes whether all music actually comes from women, whether the first glimmering of music is a mother soothing a baby. "

" Unhappiness is an unfinished state; happy people don't need our help. "

" You hope that your teenage self would like and forgive your 50-year-old self. "

" I never went to drama school, I don't have any certificates saying: 'He's a qualified actor.' But I did think that 'House' was something I didn't have to apologise for. It was something I was really proud of and it was sort of... whether you liked it or not, it was undeniable. "

" They're very harsh people, the British: hard to impress, very tough on each other, but I rather like that. It's not that the British are more honest - you're just under no illusion with them. "

" Ideas are 10 a penny. It's the execution that's the hard thing to do. House is standing up against a tide of sentiment and emotionalism over reason that threatens to engulf this world. When you think about it, a rationalist, a man of science and reason, is in a pretty lonely position. "

" I don't like the act of talking; it makes me slightly light-headed. "

" As a real person, he wouldn't last a minute, would he? But drama is about imperfection. And we've moved away from the aspirational hero. We got tired of it, it was dull. If I was House's friend, I would hate it. How he so resolutely refuses to be happy or take the kind-hearted road. But we don't always like morally good people, do we? "

" I couldn't imagine what Fox thought they were doing, contemplating such a jagged protagonist for a prime-time drama. I only knew that I wanted the role very much. "

" I'm finding it increasingly difficult to simply walk down the street. In New York, I dashed in to buy a big pair of sunglasses to conceal myself, but the guy behind the counter shouted 'Hey! It's Dr. House.' "

" I've never been clever with money. I will buy anything at the top of the market. "

" Screenwriting is the most prized of all the cinematic arts. Actually, it isn't, but it should be. "

" Muddy Waters, I suppose, was my first great hero. You know, every boy wants to be a guitar player, and Muddy Waters was just the king. He was the King Bee. He was it. "

" Seems to me that this business, for actors anyway, is not so much about whether or not you do good work. It's about whether or not you get the chance to do good work. "

" The financing of all TV shows is dictated by finding an audience between 18 and 49. I have now passed beyond 49, so probably, I am no longer a desirable commodity for TV. And I am at peace with that; that's fine. "

" Lots of people would say House doesn't have any charm at all. I would disagree, though: I find him immensely charming and endlessly entertaining. He has a sort of grace and a wit about him, and ultimately, I think he is on the side of the angels. "

" Even the greatest poets, I think, cannot quite get to the places that music can get to in the human - I was gonna say mind, but it's actually the entire body. It somehow seems to infuse the entire body. "

" Directing is the best job going. I don't understand why everybody doesn't want to direct. It's an absolutely fascinating combination of skills required and puzzles set on every level - emotional and practical and technical. It calls up on such a wide variety of skills. I find it completely absorbing. I just love the whole process. "

" Acting is largely about putting on masks, and music is about removing them. "

" L.A. runs on optimism, enthusiasm and flattery. I think you can go a little bit crazy. I've heard people say there's a limit to the number of years you can stay in this city without going slightly mad. It's just too damn sunny in every dimension - weather-wise, socially and professionally. "