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" I have always stuck up for Western medicine. You can chew all the celery you want, but without antibiotics, three quarters of us would not be here. "

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" I didn't realize House would be the central character, more the bitter comic relief appearing occasionally. I relish his wounded nature - the lameness, the scarred Byronic hero. "

" I'm reasonably easygoing. Messing up my lines or making a fool of myself is where you find my fears. Like a lot of English people, I'm prey to embarrassment - the dread that everyone's sort of sniggering at you, that you're going to look like an idiot. I think that sort of halts us all. "

" The first big stars, Bessie Smith, Ma Rainey, you know, these were gigantic stars. I even wonder sometimes whether all music actually comes from women, whether the first glimmering of music is a mother soothing a baby. "

" The great trap for non-American actors trying to play Americans, I think, is to start thinking of American-ness as a characteristic. It isn't. It is no more a character trait than height. It is just a physical fact, and that's all there is to it. "

" I couldn't imagine what Fox thought they were doing, contemplating such a jagged protagonist for a prime-time drama. I only knew that I wanted the role very much. "

" I don't talk like House, or walk like him. I certainly don't think like him. I don't like to think for more than 15 minutes at a stretch actually; I am a fragile flower. "

" I'm finding it increasingly difficult to simply walk down the street. In New York, I dashed in to buy a big pair of sunglasses to conceal myself, but the guy behind the counter shouted 'Hey! It's Dr. House.' "

" To be able to pretend to be something that I'm frankly not is very liberating and exciting. "

" I think of House as a deeply moral character, though some would no doubt argue with me. He does not judge. Beyond his normal tetchiness, there were no more than a half-dozen moments of actual condemnation from him. He understood lies and also why you lied, and there was an absolution there that is very, very appealing. "

" Humility was considered a great virtue in my family household. No show of complacency or self-satisfaction was ever tolerated. Patting yourself on the back was definitely not encouraged, and pleasure or pride would be punishable by death. "

" I think my father gave me a great reverence for medical science. He was about as opposite to the personality of House as one could imagine. He was polite and easygoing, and would have gone to great lengths to make his patients feel attended to and heard and sympathized with. "

" I don't really understand why everybody doesn't want to direct. It's an absolutely fascinating combination of skills required and puzzles set on every possible level, emotional and practical and technical. It calls upon such a wide variety of skills. I find it completely absorbing. "

" Celebrity is absolutely preposterous. Entertainment seems to be inflating. It used to be the punctuation to your life, a film or a novel or a play, a way of celebrating a good week or month. Now it feels as if it's all punctuation. "

" The glory of American television is Dennis Franz. "

" One great benefit of not being on TV every week is that people will be a lot less interested in what I have in my supermarket basket. I could even un-tint my car windows - or at least opt for a lighter shade. "

" Music is one of the noblest callings I can think of. It's the highest of all the art forms to me. For example, if my kid said to me, 'I want to give it all up,' whatever it is that they're doing, 'and I want to take my saxophone and go out,' I would say, 'May God go with you. This is a great and noble thing that you're doing.' "

" You hope that your teenage self would like and forgive your 50-year-old self. "

" Directing is the best job going. I don't understand why everybody doesn't want to direct. It's an absolutely fascinating combination of skills required and puzzles set on every level - emotional and practical and technical. It calls up on such a wide variety of skills. I find it completely absorbing. I just love the whole process. "

" I grew up with an impatience with the anti-scientific. So I'm a bit miffed with our current love affair with all things Eastern. If I sneeze on the set, 40 people hand me echinacea. But I'd no sooner take that than eat a pencil. Maybe that's why I took up boxing. It's my response to men in white pajamas feeling each other's chi. "

" I am a coffee fanatic. Once you go to proper coffee, you can't go back. You cannot go back. "

" I feel like a hostage to fortune. Not that I am complaining. I wanted to play the role. But in truth I didn't think the show would be such a success. OK, I thought it would fail. Not because it was bad. I was confident it was good, but plenty of good things just sort of wither on the vine. "

" As a real person, he wouldn't last a minute, would he? But drama is about imperfection. And we've moved away from the aspirational hero. We got tired of it, it was dull. If I was House's friend, I would hate it. How he so resolutely refuses to be happy or take the kind-hearted road. But we don't always like morally good people, do we? "

" To be a head boy, you have to be very clever, you have to be a scholar, and I was never a scholar in any shape or form. "

" Seems to me that this business, for actors anyway, is not so much about whether or not you do good work. It's about whether or not you get the chance to do good work. "

" L.A. runs on optimism, enthusiasm and flattery. I think you can go a little bit crazy. I've heard people say there's a limit to the number of years you can stay in this city without going slightly mad. It's just too damn sunny in every dimension - weather-wise, socially and professionally. "

" Muddy Waters, I suppose, was my first great hero. You know, every boy wants to be a guitar player, and Muddy Waters was just the king. He was the King Bee. He was it. "

" One of the principal goals in my life has been to avoid embarrassing my children by doing the job I do. I hope I've managed to do that, and I hope that, with the job I'm in now, they are, if not proud, at least unembarrassed by it. I must say, my three are most agreeable children, who do nothing but delight me. "

" I really do believe the camera steals the soul. But that may be because I'm worried about my soul. I don't have much of a soul to begin with; I can't afford to lose much. "

" I personally believe that the iPod is a frankly corrosive device because it encourages you to surround yourself with your favorites. The whole idea of a playlist is to surround yourself with your favorite things, and the interesting thing is that when you do that, they cease to be your favorites. "

Surround Yourself

" Piano was - well, all musical instruments were taught in this very rigid, formal, classical method when I was young. "