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" To be able to pretend to be something that I'm frankly not is very liberating and exciting. "

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" When the ship goes down, the waves very quickly roll over the top of it, and attention shifts elsewhere. It's just the natural order of things in TV - in life - and is as it should be. "

" I didn't realize House would be the central character, more the bitter comic relief appearing occasionally. I relish his wounded nature - the lameness, the scarred Byronic hero. "

" I feel like a hostage to fortune. Not that I am complaining. I wanted to play the role. But in truth I didn't think the show would be such a success. OK, I thought it would fail. Not because it was bad. I was confident it was good, but plenty of good things just sort of wither on the vine. "

" I have always stuck up for Western medicine. You can chew all the celery you want, but without antibiotics, three quarters of us would not be here. "

" I was too shy, I think, to sing publicly. It takes a particular kind of person. And when I was young, I was not that person. In the first instance, when a record company said to me, do you want to try and make your record, my first reaction was, no, I'm not worthy - I couldn't possibly, and so on and so forth. "

" Music is one of the noblest callings I can think of. It's the highest of all the art forms to me. For example, if my kid said to me, 'I want to give it all up,' whatever it is that they're doing, 'and I want to take my saxophone and go out,' I would say, 'May God go with you. This is a great and noble thing that you're doing.' "

" I have my moments. Ever since I was a boy, I never was someone who was at ease with happiness. Too often I embrace introspection and self-doubt. I wish I could embrace the good things. "

" I really do believe the camera steals the soul. But that may be because I'm worried about my soul. I don't have much of a soul to begin with; I can't afford to lose much. "

" I hate menus, I hate choosing food. I just want to be brought. Bring me dinner! "

" I don't talk like House, or walk like him. I certainly don't think like him. I don't like to think for more than 15 minutes at a stretch actually; I am a fragile flower. "

" One great benefit of not being on TV every week is that people will be a lot less interested in what I have in my supermarket basket. I could even un-tint my car windows - or at least opt for a lighter shade. "

" I don't think of myself as funny. I think of myself as rather grave, actually. And I'm suspicious of fun. I never quite know what that is or how to deal with it or how to generate it. That's my fault. I know it's a burden on the people I'm with. It's tiresome. "

" I couldn't imagine what Fox thought they were doing, contemplating such a jagged protagonist for a prime-time drama. I only knew that I wanted the role very much. "

" I think pain is a very - it's an extremely hard thing to empathize moment to moment. And you often don't remember your own pain, you know, that moment that you broke a limb or you burned yourself or, I think, this is a common thing that women talk about with childbirth, that the memory of the pain is hard to summon up and relive, thankfully. "

" I have resolved to pick one novel and just read it over and over again for the rest of my life, because I cannot remember anything anymore. "

" I think my father gave me a great reverence for medical science. He was about as opposite to the personality of House as one could imagine. He was polite and easygoing, and would have gone to great lengths to make his patients feel attended to and heard and sympathized with. "

" Screenwriting is the most prized of all the cinematic arts. Actually, it isn't, but it should be. "

" Girls are complicated. The instruction manual that comes with girls is 800 pages, with chapters 14, 19, 26 and 32 missing, and it's badly translated, hard to figure out. "

" I think maybe even one of the reasons I became an actor was actually to hide. I mean, it sounds paradoxical because, of course, people are standing up in a public place and encouraging other people to look at them. So that's not the conventional definition of hiding. "

" I think actors are attracted to the idea of other identities and concealing themselves behind some other identity. "

" My dad gave me my first bike at 16. I soon fell off and was in a wheelchair for weeks. I haven't fallen since. "

" They're very harsh people, the British: hard to impress, very tough on each other, but I rather like that. It's not that the British are more honest - you're just under no illusion with them. "

" I don't have a single complete show or movie or anything else that I could look at and say, 'Nailed that one.' But endless dissatisfaction is, I suppose, what gets us out of bed in the morning. "

" I feel when acting, I am sometimes overly self-conscious; I think, 'Going, no, don't, put your eyebrow back where it was and, you know, turn to the left.' You know, I'm sort of very consciously adopting this character. But with music, I don't know. I found it was a question of just closing my eyes and just sort of letting things come out. "

" Ideas are 10 a penny. It's the execution that's the hard thing to do. House is standing up against a tide of sentiment and emotionalism over reason that threatens to engulf this world. When you think about it, a rationalist, a man of science and reason, is in a pretty lonely position. "

" I wouldn't be able to act like Al Pacino or play the piano like Dr. John, But I could probably act better than Dr. John and play the piano better than Al Pacino. "

" I think of House as a deeply moral character, though some would no doubt argue with me. He does not judge. Beyond his normal tetchiness, there were no more than a half-dozen moments of actual condemnation from him. He understood lies and also why you lied, and there was an absolution there that is very, very appealing. "

" Piano was - well, all musical instruments were taught in this very rigid, formal, classical method when I was young. "

" Believe it or not, perhaps I don't show it much, or well, but I think I like people. "

" I've never been clever with money. I will buy anything at the top of the market. "