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" It's never been a priority for me to concentrate on the likability of the character. "

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" You can't really claim too much ownership of your character. They really do belong to the writers, and in many ways, you're just their puppet. "

" You get to a certain point - gratefully - when you're out of your twenties, and you realize how fleeting life is. So, it becomes important to feel as if the people in your life know exactly how you feel about them at all times. "

" I watch '60 Minutes' and 'Dateline' and '20/20.' I work in fantasy all day, so when I go home I want to touch reality. "

" As they say, there are two rules in improv: Never say no, and never ask why. When another actor asks 'Why?' or says no to something you're suggesting, then it's very clear that they're putting the onus on you, because they're not comfortable with it themselves. "

" There is that stereotype of a nerd with the high pants and pocket protector and that kind of thing. That can sustain comedy for maybe a movie - hence the 'Revenge of the Nerds' franchise - but not for hopefully years on the air. It's a sight gag, not a story. "

" I love to work. I absolutely love to work. "

" We can't really do any improv on 'The Big Bang' because we don't understand a lot of what the dialogue means to begin with, because of the physics jargon. "

" You know, I read the papers and I watch the news a lot. I watch 'Dateline' and '48 Hours'. And I think we have a tendency to become terrified of one another, thinking that there is a serial killer that is on either side of you. "

" I used to know Jennifer Love Hewitt. We lived in the same apartment building when I was about... jeez, I guess it was when I was doing 'Christmas Vacation', so I was about 13 or 14. "

" It's that one thing that you're passionate about, that you end up developing tunnel vision for and everything else tends to fall by the wayside. Passion is appealing and universal. "

" 'Entourage' is a great show, but it's fantasy. I spent my twenties in L.A. in this business, and my life didn't look anything like that. 'Big Bang' reflects a side of men that is rarely shown. We see their flaws - all of them. "

" I bought a little hideaway up north, so I'll ship my motorcycle up there. It's much less dangerous than West Hollywood. "

" I read the papers, and I watch the news a lot. I watch 'Dateline' and '48 Hours.' And I think we have a tendency to become terrified of one another, thinking that there is a serial killer that is on either side of you. "

" When you read the news, and you see all this bad stuff happening, there's a tendency to lose faith in humanity. But I meet so many people who restore it and realize that, actually, 99 percent of people are great. "

" Theater audiences don't pull punches. They'll let you know when they're feeling ripped off. "

" Comedy is similar to hockey... in only one way. You get a lot of credit for assists. So I try to serve whatever the intention is, be it the joke or the story or the scene or the moment or the kiss, even if it's not my joke or moment. "

" I was the sibling that kind of kept it all on a level when life at home got tough. I did it through comedy, sarcasm and distraction. All families are complicated, but my home life was glaringly uncomfortable much of the time, and it was me that took the onus. "

" People are complicated; you put two of them together and it's generally a mess, but hopefully a beautiful mess. "

" I don't know what to do with myself between films. I end up doing unhealthy things like shopping or drinking. I'm pretty schizophrenic about it. "

" When I grew up, scientists were anti-social people who worked in basements and wore coats and worked with bunson burners, and now they're in our technology every day, and our technology has almost become fashion accessories. "

" I know a lot of incredibly, profoundly talented, skilled people that aren't given certain opportunities or any opportunities, and that aren't working. "

" I'm a fan of music in general. "

" When I'm back home in Chicago, since 'Roseanne' was such a Midwestern, blue-collar show, that's what sticks out in people's minds. "

" I'm still a Chicagoan in the fact that I can't do Christmas with sand and palm trees. It just doesn't compute - it's not Christmas unless your face hurts when you step outside. "

" I work in fantasy all day, so when I go home, I want to touch reality. "

" People always ask about learning all of your lines as an actor, and it's generally the easiest part of the job. "

" We've all seen great actors and actresses who are missing a certain chemistry. And it's not about getting along or not getting along. "

" Right now, I'm very healthy. I have no vices left. Except sugary breakfast cereal. And absinthe, of course. "

" My parents would have their friends over - their friends who thought, 'How can you live without a TV?' By the time they left, they understood why, because I had done the second act of 'West Side Story' and the first act of 'Jesus Christ Superstar,' playing all the parts. In many ways, that's what I'm still doing. I'm just getting paid better. "

" When I started on 'Roseanne,' it was a great achievement for me at the time. But I wasn't a part of building it; I wasn't a carpenter in creating that juggernaut. "