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" We can't really do any improv on 'The Big Bang' because we don't understand a lot of what the dialogue means to begin with, because of the physics jargon. "

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" I'm not at my best when I'm not working - I'm certainly not at my happiest. Acting will always be my first love. "

" Scientists are not these guys in lab coats deep in the inner bowels of universities and hospitals with their Bunsen burners. They're the people molding the culture that we live in, the future of our culture, and the technology we rely on every day. These are the rock stars of our time right now. "

" Comedy is similar to hockey... in only one way. You get a lot of credit for assists. So I try to serve whatever the intention is, be it the joke or the story or the scene or the moment or the kiss, even if it's not my joke or moment. "

" When I'm back home in Chicago, since 'Roseanne' was such a Midwestern, blue-collar show, that's what sticks out in people's minds. "

" I'm a fan of music in general. "

" When I grew up, scientists were anti-social people who worked in basements and wore coats and worked with bunson burners, and now they're in our technology every day, and our technology has almost become fashion accessories. "

" Perhaps 'Big Bang' fans feel so protective of the show because it is, despite being a hit show on a big network, something of a word-of-mouth phenomenon. "

" I'm still a Chicagoan in the fact that I can't do Christmas with sand and palm trees. It just doesn't compute - it's not Christmas unless your face hurts when you step outside. "

" As they say, there are two rules in improv: Never say no, and never ask why. When another actor asks 'Why?' or says no to something you're suggesting, then it's very clear that they're putting the onus on you, because they're not comfortable with it themselves. "

" We've all seen great actors and actresses who are missing a certain chemistry. And it's not about getting along or not getting along. "

" You get to a certain point - gratefully - when you're out of your twenties, and you realize how fleeting life is. So, it becomes important to feel as if the people in your life know exactly how you feel about them at all times. "

" 'Entourage' is a great show, but it's fantasy. I spent my twenties in L.A. in this business, and my life didn't look anything like that. 'Big Bang' reflects a side of men that is rarely shown. We see their flaws - all of them. "

" I used to know Jennifer Love Hewitt. We lived in the same apartment building when I was about... jeez, I guess it was when I was doing 'Christmas Vacation', so I was about 13 or 14. "

" In a series, you really need to stay open-minded. It's not like a play or a film, where you can create and fully commit to your character's back-story. "

" I work in fantasy all day, so when I go home, I want to touch reality. "

" We didn't have a TV because we didn't have a whole lot of money. My parents would have their friends over - their friends who thought, 'How can you live without a TV?' "

" My parents would have their friends over - their friends who thought, 'How can you live without a TV?' By the time they left, they understood why, because I had done the second act of 'West Side Story' and the first act of 'Jesus Christ Superstar,' playing all the parts. In many ways, that's what I'm still doing. I'm just getting paid better. "

" I bought a little hideaway up north, so I'll ship my motorcycle up there. It's much less dangerous than West Hollywood. "

" It's that one thing that you're passionate about, that you end up developing tunnel vision for and everything else tends to fall by the wayside. Passion is appealing and universal. "

" When I started on 'Roseanne,' it was a great achievement for me at the time. But I wasn't a part of building it; I wasn't a carpenter in creating that juggernaut. "

" I love to work. I absolutely love to work. "

" People are complicated; you put two of them together and it's generally a mess, but hopefully a beautiful mess. "

" People always ask about learning all of your lines as an actor, and it's generally the easiest part of the job. "

" Right now, I'm very healthy. I have no vices left. Except sugary breakfast cereal. And absinthe, of course. "

" I read the papers, and I watch the news a lot. I watch 'Dateline' and '48 Hours.' And I think we have a tendency to become terrified of one another, thinking that there is a serial killer that is on either side of you. "

" When you read the news, and you see all this bad stuff happening, there's a tendency to lose faith in humanity. But I meet so many people who restore it and realize that, actually, 99 percent of people are great. "

" You can't really claim too much ownership of your character. They really do belong to the writers, and in many ways, you're just their puppet. "

" I'm not at all competitive. I'd rather play Solitaire than ping-pong. "

" I don't know what to do with myself between films. I end up doing unhealthy things like shopping or drinking. I'm pretty schizophrenic about it. "

" I watch '60 Minutes' and 'Dateline' and '20/20.' I work in fantasy all day, so when I go home I want to touch reality. "