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" We've all seen great actors and actresses who are missing a certain chemistry. And it's not about getting along or not getting along. "

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" We can't really do any improv on 'The Big Bang' because we don't understand a lot of what the dialogue means to begin with, because of the physics jargon. "

" We didn't have a TV because we didn't have a whole lot of money. My parents would have their friends over - their friends who thought, 'How can you live without a TV?' "

" It's never been a priority for me to concentrate on the likability of the character. "

" I was the sibling that kind of kept it all on a level when life at home got tough. I did it through comedy, sarcasm and distraction. All families are complicated, but my home life was glaringly uncomfortable much of the time, and it was me that took the onus. "

" When I grew up, scientists were anti-social people who worked in basements and wore coats and worked with bunson burners, and now they're in our technology every day, and our technology has almost become fashion accessories. "

" I know a lot of incredibly, profoundly talented, skilled people that aren't given certain opportunities or any opportunities, and that aren't working. "

" I'm not at my best when I'm not working - I'm certainly not at my happiest. Acting will always be my first love. "

" There is that stereotype of a nerd with the high pants and pocket protector and that kind of thing. That can sustain comedy for maybe a movie - hence the 'Revenge of the Nerds' franchise - but not for hopefully years on the air. It's a sight gag, not a story. "

" I was a huge theater geek growing up, and that was not the easiest thing in the world, especially growing up in Chicago, where sports are really the norm. I was always off to the theater at night, from 7 years old on. Friends there in the Midwest who could talk to you about the idiosyncrasies of 'Pippin' were few and far between. "

" I'm still a Chicagoan in the fact that I can't do Christmas with sand and palm trees. It just doesn't compute - it's not Christmas unless your face hurts when you step outside. "

" My parents would have their friends over - their friends who thought, 'How can you live without a TV?' By the time they left, they understood why, because I had done the second act of 'West Side Story' and the first act of 'Jesus Christ Superstar,' playing all the parts. In many ways, that's what I'm still doing. I'm just getting paid better. "

" I watch '60 Minutes' and 'Dateline' and '20/20.' I work in fantasy all day, so when I go home I want to touch reality. "

" Scientists are not these guys in lab coats deep in the inner bowels of universities and hospitals with their Bunsen burners. They're the people molding the culture that we live in, the future of our culture, and the technology we rely on every day. These are the rock stars of our time right now. "

" Perhaps 'Big Bang' fans feel so protective of the show because it is, despite being a hit show on a big network, something of a word-of-mouth phenomenon. "

" It took me a long time to realize that to walk around without a certain amount of belief in myself, to walk onto a job with my tail between my legs, wasn't behooving anyone else. "

" You can't really claim too much ownership of your character. They really do belong to the writers, and in many ways, you're just their puppet. "

" When I'm back home in Chicago, since 'Roseanne' was such a Midwestern, blue-collar show, that's what sticks out in people's minds. "

" I read the papers, and I watch the news a lot. I watch 'Dateline' and '48 Hours.' And I think we have a tendency to become terrified of one another, thinking that there is a serial killer that is on either side of you. "

" As they say, there are two rules in improv: Never say no, and never ask why. When another actor asks 'Why?' or says no to something you're suggesting, then it's very clear that they're putting the onus on you, because they're not comfortable with it themselves. "

" It's always interesting for me to watch the pilot of an established show because you see how the writers and actors weren't really sure what the show was and what the dynamics were. If you look at the pilot for 'Seinfeld,' for example, it's practically unrecognizable. "

" I'm a fan of music in general. "

" I bought a little hideaway up north, so I'll ship my motorcycle up there. It's much less dangerous than West Hollywood. "

" I used to know Jennifer Love Hewitt. We lived in the same apartment building when I was about... jeez, I guess it was when I was doing 'Christmas Vacation', so I was about 13 or 14. "

" In a series, you really need to stay open-minded. It's not like a play or a film, where you can create and fully commit to your character's back-story. "

" I don't know what to do with myself between films. I end up doing unhealthy things like shopping or drinking. I'm pretty schizophrenic about it. "

" I work in fantasy all day, so when I go home, I want to touch reality. "

" 'Entourage' is a great show, but it's fantasy. I spent my twenties in L.A. in this business, and my life didn't look anything like that. 'Big Bang' reflects a side of men that is rarely shown. We see their flaws - all of them. "

" When you read the news, and you see all this bad stuff happening, there's a tendency to lose faith in humanity. But I meet so many people who restore it and realize that, actually, 99 percent of people are great. "

" People are complicated; you put two of them together and it's generally a mess, but hopefully a beautiful mess. "

" You know, I read the papers and I watch the news a lot. I watch 'Dateline' and '48 Hours'. And I think we have a tendency to become terrified of one another, thinking that there is a serial killer that is on either side of you. "