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" One year at the SAG Awards, somebody practically knocked me over, and it was Helen Mirren. She was like, 'Oh my God - is it really you? I'm your biggest fan.' I was like, 'Wait, aren't you supposed to be home reading Shakespeare or something?' "

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" I never had a burning desire to have children. But then I met Nick, and I thought, 'This is the only person I'd do this with.' So we tried, but I was a little long in the tooth for that sort of thing. But we didn't turn it into a soap opera. We tried for about a year or so, and it didn't happen and took that to mean it wasn't meant to be. "

Megan Mullally

Person

Thought

Long

" I feel like Nick and I have the best relationship and the best marriage. "

Megan Mullally

Best

Relationship

" I can understand everybody associates me with Karen, but beyond that, I think after time passes and a few years go by, that sort of becomes a non-issue. That character is far - I mean really, all the characters I've played are pretty far away from what I'm really like. "

Megan Mullally

Character

Time

" Multi-camera's fun because you have the immediacy of the audience and just being able to tell the story more or less straight through. The thing I like about single-camera is that you have the luxury of shooting a lot of different options. "

" If we're ever seen having a public spat in a coffee shop, I think the concept of romance will die. "

" At first, people were like, 'I've discovered something - you guys are married!' I was like, 'Yeah, that's not a secret. We've been married now already for many years.' "

" Sean is so funny. One time he went to Ireland for two weeks with his mother, and Ireland is so beautiful, and he got back; we were like, 'How was it?' and he was like, 'Ugh I was so bored.' "

" I think theater is more about living and breathing, versus TV, which can vary. "

" I love Chicago - absolutely love Chicago. I mean, I'd much rather go to Chicago and do a play or a musical than New York, honestly. Because just probably for reasons that are obvious to you. It's just a little bit - it's a nicer, easier city. "

" I love creating new characters that are whatever they are. "

" Playing Karen was so satisfying that it almost cured my acting bug completely. Not that I had conquered the world of acting. It was just that I had something to prove to myself when I started Will & Grace. Now I feel like, okay, well, I've satisfied that. "

" I had a lot of friends for a long time who were gay, and I didn't even realize it for awhile. Even in my mid- to late 20s, I was still pretty naive about it. "

" Nick's just from this very Norman Rockwell-ish family. They're very 'American Gothic,' and his parents are so kind, and they're not brash people; they're very soft spoken, salt of the earth. "

" You can't really be super conservative and continue to keep your audience, but at least the audience that we attract comes with a certain level of naughtiness. "

" I get deep into the creative aspect, and Nick is the people person. "

" We met in April of 2000, and we weren't really an official couple until June or July. His family has a fishing trip they go on every year in Minnesota, so he had invited me to go and meet his whole family. There was, like, no cell phone service at the time; people were using those giant cordless phones that looked like a brick. "

" Karen was always such a lawless rebel: carrying a gun in her purse, flirting with 14-year-old boys. She's the worst. You know that horrible guy Milo Yiannopoulos? She has about as many redeeming qualities as he has. "

" Nick gets carsick if he's not driving - plus, he's basically a walking atlas. He can drive around any city without a map, which works out fine for me because I just become our entertainment director and pick out which audio book we'll listen to next. "

" I think of myself as a character actress, and Karen's just one of the characters I've gotten to play, but I feel like Karen takes on so much more weight because the show was on for eight seasons, and it was such a popular show. But you have to move on to telling another story in a different world. "

" I kind of connected the dots, like, 'Oh, we're just saying stuff. We're just saying things that make sense, so let's just say them like you say them in real life.' It was my first and one of my only acting lessons 'cause I never really studied acting. "

" Nobody knew if the pilot would even get picked up because it had two gay lead characters, which has never happened before. And now every show has at least two gay characters, if not many more. "

" My mom is elderly, and she's not doing too well, and I've literally never told her about 'Childrens Hospital,' because I fear that if she ever sees it, it will be like the coup de grace. "

" People get up and say, 'I didn't prepare a speech because I didn't think I would win.' Well, that's dumb. "

" Now, it's weird not to have gay characters on a show. "

" During 'Will & Grace,' we had so many things we had to go to where you get all dolled up. It's like pulling teeth for me. "

Megan Mullally

You

Will

" We do jigsaw puzzles. Here's a pro tip: Listen to an audiobook while doing it. "

" A lot of people are saying it's an inspiration to see a couple who are in love and getting a kick out of each other. "

" I think a lot of actors, maybe who have been on a hit show and been lucky enough to get successful, might say 'no' more than I do. And maybe that's good, maybe that's smart. I don't know. "

" My mom was extremely supportive of me, but it could err on the side of... I mean, there's supportive, and then there's just full-on over-hovering. "

" All the writers on our show went in and got in the bed and took a picture in Cher's bed, even though she was never in it. "