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" Now, it's weird not to have gay characters on a show. "

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" I feel like Nick and I have the best relationship and the best marriage. "

" Nick's just from this very Norman Rockwell-ish family. They're very 'American Gothic,' and his parents are so kind, and they're not brash people; they're very soft spoken, salt of the earth. "

" I'll quit coffee. It won't be easy drinking my Bailey's straight, but I'll get used to it. It'll still be the best part of waking up. "

" I kind of connected the dots, like, 'Oh, we're just saying stuff. We're just saying things that make sense, so let's just say them like you say them in real life.' It was my first and one of my only acting lessons 'cause I never really studied acting. "

" I never had a burning desire to have children. But then I met Nick, and I thought, 'This is the only person I'd do this with.' So we tried, but I was a little long in the tooth for that sort of thing. But we didn't turn it into a soap opera. We tried for about a year or so, and it didn't happen and took that to mean it wasn't meant to be. "

" Theater is great because you're able to tell a narrative arc without a break. I think it's more about the material and whether what we get offered is good. "

" I think a lot of actors, maybe who have been on a hit show and been lucky enough to get successful, might say 'no' more than I do. And maybe that's good, maybe that's smart. I don't know. "

" I'm from Oklahoma, and Nick's from a small town in Illinois. "

" Karen is like RuPaul - she's a character. It never occurred to me until now, but she is! "

" I tend to let the chips fall where they may. I don't know if that's right or wrong. "

" That's all you ever want - to do your job well enough that people on the other end are happy. "

" Isn't that sort of what happened with gay marriage? Right before gay marriage was legalized, everybody was just losing their minds and, like, the worst possible things were happening, and it was just all like it couldn't get any worse, and then it suddenly got a lot better. "

" All the writers on our show went in and got in the bed and took a picture in Cher's bed, even though she was never in it. "

" I secretly had this name 'Nancy and Beth' come into my mind, and I thought, 'Oh my God, that's such a funny, interesting, weird name for a band.' "

" I'm a big hit with guards at security. They're the center of my fan base, the airport security guards. "

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" People are always flabbergasted, like, 'You sing?' "

" My mom is elderly, and she's not doing too well, and I've literally never told her about 'Childrens Hospital,' because I fear that if she ever sees it, it will be like the coup de grace. "

" Multi-camera's fun because you have the immediacy of the audience and just being able to tell the story more or less straight through. The thing I like about single-camera is that you have the luxury of shooting a lot of different options. "

" I think of myself as a character actress, and Karen's just one of the characters I've gotten to play, but I feel like Karen takes on so much more weight because the show was on for eight seasons, and it was such a popular show. But you have to move on to telling another story in a different world. "

" I lived in Chicago in the early '80s and did a ton of theater, and then Nick lived there in the '90s and did a ton of theater. Then we both moved to L.A. and did a ton of television. "

" Playing Karen was so satisfying that it almost cured my acting bug completely. Not that I had conquered the world of acting. It was just that I had something to prove to myself when I started Will & Grace. Now I feel like, okay, well, I've satisfied that. "

" I certainly have gay friends, but I don't remember thinking, 'Oh my God, I have this friend, and they're gay, and that's so cool.' I mean, I was very naive until I got to a certain age. "

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" Why can't I ever play a nice, normal, salt-of-the-earth type? Is there something I should know? It's fun to play villains and character roles, of course - but I'm sure it's also fun to be a really big star and play the lead in everything, where all you have to do is show up and not blink. "

" I get offered stuff that I don't really want to do, so hopefully, I'm just kind of waiting for the right thing. "

" Madonna was very cool. I thought she was really nice, really present, and she worked really, really hard... She didn't necessarily know our real names in real-life, because why should she? Who cares? Some of the cast were really offended, like, 'She doesn't even know my name!' I'm like, 'Who cares? Madonna's doing our show. It doesn't matter.' "