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" The currencies of science are discoveries and ideas; the rewards are the excitement of going where nobody has been before and, if one is inclined to such things, the kudos of peer acclaim, plus funds to do more research. "

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" When it came to choice of subjects, science was obvious - since I was uninterested in anything else - but a decision that caused consternation in some eyes was my demand to take biology for A-level. "

John Sulston

Eyes

Choice

Science

" It was a matter of not living lavishly but enjoying what you had, growing things with your hands, working hard, but not being tied to a nine-to-five job, and generally feeling that there's more to life than money. "

" The strong evidence is that we're running out of space. We're collectively affecting the world's climate. This is due to the still-growing human population and our increase in consumption. "

" In science, as in business, there must be structures that ensure the well endowed do not use their position to block competition. "

" You have to say - and I do - that anything that blocks that cheapest possible point-of-care delivery of health is wrong. "

" Science and the many benefits that science has produced have played a crucial part in our history and produced vast improvements to human welfare. "

" I don't think one ought to bring a clearly disabled child into the world. "

" When results are shared freely amongst the biological community, as has been done for the worm and the Human Genome Projects, specialist scientists can move much more rapidly towards their goals. "

" Whilst worthy in themselves, applications shouldn't be the only way to drive basic research. "

" There's always a tension between those who would like to garner wealth, and they contribute a lot to society. There's also those who say, 'I believe in the common good. I want that to be enlarged.' They contribute a lot to society. The tension, the debate, between these two views is extremely important to our progress. "

" It is very clear that the present system of innovation for medicines is very inefficient and really somewhat corrupt. It benefits shareholders over patients; it produces for the rich markets and not for the poor and does not produce for minority diseases. "

" As far back as I remember, and earlier, I was an artisan, a maker and doer. Mechanically minded, my parents said. "

" I would say if we can select children who are not going to be severely disadvantaged, then we should do so, but I think it has to be done by voluntary choice. "

" I'm pleased that some economists and sociologists are beginning to talk about, for example, alternative measures of human well-being - alternative, that is, to GDP, on which the world runs. "

" On my mother's side, I come from Midlands engineers and, on my father's, from tenant farmers near Oxford. "

" We knew that all the protein-coding bits of genes do is to produce protein - they have to have instructions to turn them on and off. Those sequences lie well outside the protein-coding sequences, sometimes thousands, tens of thousands of bases away. "

" If you patent a discovery which is unique, say a human gene or even just one particular function of a human gene, then you are actually creating a monopoly, and that's not the purpose of the world of patents. "

" The fact is that proprietary databases don't work for such basic and broadly needed information as the sequence of the human genome. "

" The free market is the epitome of life itself. This is something that all scientists recognise because science itself operates on free market lines. "

" I don't want a few extra weeks of life at enormous cost, for example, when it comes to the end. "

" Muriel, my mother, was my main confidant. She was a teacher of English at Watford grammar school but took a break while my sister Madeleine and I were children. She held court in the kitchen, and we talked about everything. "

" Our work on C. elegans emphasized the benefits of sharing large amounts of information. We took a global approach to discover the mechanisms that led to the development of the worm. "

" I believe our basic information, our 'software', should be free and open for everyone to play with, to compete with, to try and make products from. I do not believe it should be under the control of one person. "

" In order to protect the market value of a proprietary database, the owner must prohibit redistribution of the contents - otherwise, the information would quickly leak out and be widely known. "

" It is not a Pandora's box that science opens; it is, rather, a treasure chest. We, humanity, can choose whether or not to take out the discoveries and use them, and for what purpose. "

" What is the purpose of being human and alive without doing new things? "

" If we understand the worm, we understand life. "

" The only thing I have retained from my upbringing - I did not retain the religious element - is the idea that you do not do things for money. "

" The human world lives in a framework called global economics. We live in a system based on GDP, which drives consumption. it causes people to compete with each other through trade in a way that they all grow. "

" Biomedical research is only as good as its delivery. Distribution of medicines by charities is no more than a stopgap. "

John Sulston

Research

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