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" When it came to choice of subjects, science was obvious - since I was uninterested in anything else - but a decision that caused consternation in some eyes was my demand to take biology for A-level. "

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" The fact is that proprietary databases don't work for such basic and broadly needed information as the sequence of the human genome. "

John Sulston

Genome

Information

Work

" Many people thought that, given my knowledge of the egg, I should analyse embryonic mutants. "

" There's always a tension between those who would like to garner wealth, and they contribute a lot to society. There's also those who say, 'I believe in the common good. I want that to be enlarged.' They contribute a lot to society. The tension, the debate, between these two views is extremely important to our progress. "

" The human world lives in a framework called global economics. We live in a system based on GDP, which drives consumption. it causes people to compete with each other through trade in a way that they all grow. "

" In order to protect the market value of a proprietary database, the owner must prohibit redistribution of the contents - otherwise, the information would quickly leak out and be widely known. "

" I'm pleased that some economists and sociologists are beginning to talk about, for example, alternative measures of human well-being - alternative, that is, to GDP, on which the world runs. "

" Biomedical research is only as good as its delivery. Distribution of medicines by charities is no more than a stopgap. "

John Sulston

Research

Only

" Our work on C. elegans emphasized the benefits of sharing large amounts of information. We took a global approach to discover the mechanisms that led to the development of the worm. "

" I believe our basic information, our 'software', should be free and open for everyone to play with, to compete with, to try and make products from. I do not believe it should be under the control of one person. "

" When results are shared freely amongst the biological community, as has been done for the worm and the Human Genome Projects, specialist scientists can move much more rapidly towards their goals. "

" The Wellcome Trust is a hugely important organisation, and it is vital that its fundraising continues unabated. "

" The only thing I have retained from my upbringing - I did not retain the religious element - is the idea that you do not do things for money. "

" If we understand the worm, we understand life. "

" Whilst worthy in themselves, applications shouldn't be the only way to drive basic research. "

" The strong evidence is that we're running out of space. We're collectively affecting the world's climate. This is due to the still-growing human population and our increase in consumption. "

" The currencies of science are discoveries and ideas; the rewards are the excitement of going where nobody has been before and, if one is inclined to such things, the kudos of peer acclaim, plus funds to do more research. "

John Sulston

Research

Ideas

" As far back as I remember, and earlier, I was an artisan, a maker and doer. Mechanically minded, my parents said. "

" If you patent a discovery which is unique, say a human gene or even just one particular function of a human gene, then you are actually creating a monopoly, and that's not the purpose of the world of patents. "

" Science and the many benefits that science has produced have played a crucial part in our history and produced vast improvements to human welfare. "

" Title deeds establish and protect ownership of our houses, while security of property is as important to the proprietors of Tesco and Sainsbury's as it is to their customers. "

" It is very clear that the present system of innovation for medicines is very inefficient and really somewhat corrupt. It benefits shareholders over patients; it produces for the rich markets and not for the poor and does not produce for minority diseases. "

" It is not a Pandora's box that science opens; it is, rather, a treasure chest. We, humanity, can choose whether or not to take out the discoveries and use them, and for what purpose. "

" We can choose to address the twin issues of population and consumption to rebalance the use of resources to a more egalitarian pattern of consumption. "

" You have to say - and I do - that anything that blocks that cheapest possible point-of-care delivery of health is wrong. "

" I don't think one ought to bring a clearly disabled child into the world. "

" What is the purpose of being human and alive without doing new things? "

" We knew that all the protein-coding bits of genes do is to produce protein - they have to have instructions to turn them on and off. Those sequences lie well outside the protein-coding sequences, sometimes thousands, tens of thousands of bases away. "

" I would say if we can select children who are not going to be severely disadvantaged, then we should do so, but I think it has to be done by voluntary choice. "

" An awful lot of food is thrown away. This you can call a spillover. It doesn't sort of enter into our economic system because it's a consequence of running things in a highly competitive way: the free market, global pricing and so on. "

" The fruits of science and innovation have nourished our society and economy for years, but nations unable to navigate our regulatory system are often excluded, as are vulnerable individuals. "