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" The Simpsons are ugly-looking, and they should be. That's what works. That's one of the things that's funny. "

Seth MacFarlane

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" You don't want to be nasty for the sake of being nasty. "

Seth MacFarlane

" The success of 'The Simpsons' really opened doors. It showed that if you were working in animation you didn't necessarily have to be working in kids' television. "

Seth MacFarlane

" People do that on Facebook and it's the dumbest thing in the world. I don't care what your dinner looks like. Stop cluttering up the Internet with pictures of your dinner. "

Seth MacFarlane

" I did a lot of theater when I was in high school and college. I also did stand-up in college, so it was always part of what I did. "

Seth MacFarlane

" I love the English. My God, they brought us 'Benny Hill,' 'Monty Python,' 'The Office,' Neville Chamberlain. "

Seth MacFarlane

" The way Disney characters move, they're very kind of slow and fluid and flowing; one pose kind of eases into the next. If you look at a show like 'The Simpsons' and subsequently a show like 'Family Guy' - the characters will jerk from pose to pose a lot, a bit more snappy. Which sort of goes along with the writing tone of the show. "

Seth MacFarlane

" The resistance to science is idiotic. "

Seth MacFarlane

" There are times when I'm under the weather and the corporate machine tries to put me in the recording booth anyway. It's always up to me to say, 'Guys, listen to me, listen to what I sound like. I'm not myself.' "

Seth MacFarlane

" With any half-hour comedy, it kind of takes on its own life and finds itself. "

Seth MacFarlane

" I'm one of the few people in Hollywood who actually had a good childhood. "

Seth MacFarlane

" You would not want me on your football team. "

Seth MacFarlane

" The trend today is vampires, zombies, angels, all the stuff that puts me right to sleep. It's too bad because it's so much less interesting than the diversity of stories you can tell with science. "

Seth MacFarlane

" I have a car that I like - an Aston Martin - for Sunday drives in the country. "

Seth MacFarlane

" I think at times I read too much of my own press. I wish I was better at taking in how great my life is, but that's surprisingly elusive. I tend to be very hard on myself and insecure about failing no matter what happens. "

Seth MacFarlane

" There are people on staff who have made that point, that the upside to a second Bush term is that it makes 'American Dad' work better. To me, the price is too high. I would gladly give up the comedy to have a President Kerry. But you work with what you have. "

Seth MacFarlane

" There have to be people who are vocal about the advancement of knowledge over faith. "

Seth MacFarlane

" Science has become politicized, and that's an embarrassment. "

Seth MacFarlane

" On a certain day, I will tweet five times, and then I'll go four days without tweeting at all. It really depends on what time allows. Twitter, priority-wise, has to come after the work is done. "

Seth MacFarlane

" The worst thing to happen at the Oscars would be if nothing happened. You want something unscripted, something to riff on, something kinda out there. "

Seth MacFarlane

" I can't believe I am hosting the Oscars. It's an honor everyone else said no. "

Seth MacFarlane

" The average person has eight different jobs over the course of their lifetime. You get a little antsy doing the same thing. "

Seth MacFarlane

" You gotta keep the funny intact. "

Seth MacFarlane

" Denzel Washington has a great sense of humor. He did all those 'Nutty Professor' movies. "

Seth MacFarlane

" Fox is notorious for having a very thick skin about taking shots at themselves. "

Seth MacFarlane

" Everybody in my family had a real sick, twisted sense of humor. Most of the jokes we make in our house, we would just never even dream of making anywhere else. Just sick, horrible stuff. That wasn't anything new to college. "

Seth MacFarlane

" I was a huge 'Star Trek' fan. I loved the 'Twilight Zone' growing up. In the future, I hope to create some thoughtful, sci-fi drama. "

Seth MacFarlane

" Some of those more out-there jokes were written in the wee hours of the morning. Somehow, they remained funny the next day. "

Seth MacFarlane

" I was about two years old when I first started drawing recognizable characters. "

Seth MacFarlane

" We never really tried to shock for shock's sake on 'Family Guy'. If something was horribly offensive and shocking, we would put it in if it was also hysterically funny. "

Seth MacFarlane

" I'm big on the importance of science, particularly right now at this point in time when there's sort of a systematic rejection of science by a lot of people in America. "

Seth MacFarlane