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" Being a mother is the ultimate training ground for anything. "

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" When you hit your 40s, you're walking around, and you realize, 'Oh, my God, men don't look at me anymore.' Or sometimes you can feel really good, and then you look in the mirror, and you're like, 'Oh, Jesus, that's my face now!' But I have tell you that something happened and shifted inside of me. "

" I just like to keep things small and subtle and authentic, and ground everything in reality. So that is something that I feel is my strength as a director and I try to achieve as an actor. "

" They would call me 'The Cleaner' because I would replace boys who were real adolescents, and their voices completely changed, and they couldn't do the voices anymore. "

" Sometimes when I'm in the car driving, I scream at the top of my lungs. "

" I took my daughters to see Plastic Ono Band at the Orpheum in L.A. in 2012. It was an amazing experience because she is such a revolutionary artist. Everybody was like, 'Oh, it's Yoko, it's such a joke.' But it's no joke what she did, visually and musically. It's incredible. "

" I always tell young people when I'm trying to encourage them, 'You have certain windows in your life, and you have to take advantage of it. You gotta jump through because they will shut on you.' "

" I learned so much from the writing on 'King of the Hill', which I thought was just magnificent. They would let real moments happen in this animated, one-dimensional world. I feel like I've been in school this whole time. "

" I don't like to let people know where I'm going to end up, and I don't personally like to know where I'm going. "

" The thing about women playing boys is that we're not going to age, and we're not going to go through puberty in the middle of a long-running series. "

" I'm very influenced by documentary filmmaking and independent filmmaking, by a lot of noir and films from the '40s. Those are my favorite. And then, filmmaking from the '70s is a big influence for me. "

" I like people to have their own reaction and their own take on things. And I don't like to shove my - what I want them to feel or think - down their throats. I like people to say, 'What was that about?' or 'Why did that happen?' And so, any reactions are welcome. "

" I love that, 'mommy-shaming.' When I was a new mom, I was obsessed with how I was being perceived and trying to fit in as a mom, going to mommy-and-me classes and things like that, and never quite measuring up to 'the real moms,' the 'robot moms,' as I called them. "

" It's a hilarious part of my past, all the sitcoms I did in the '80s. And then all the animation - animation is amazing. It's really been great. "

" I try to direct myself the way I direct the other actors who come on my show. "

" I don't usually say 'working mom' because I think all moms are working moms. I feel like that diminishes moms. People should say 'working dad' as opposed to working moms. "

" I get up at 6 A.M., and sometimes I make lunch for my two youngest kids. Usually my oldest sleeps late, and I get my kids out the door to school. For years, it was me just doing all of that and then driving to a carpool or this or that. "

" Everything that happens to me in a day enhances my parenting. "

" My roles in the '80s were, like, gender dysphoric. I wasn't pretty, I wasn't this, I wasn't that. And I am kind of butchy, you know. That's just my thing. "

" Before 'Lucky Louie,' nobody would ever cast me to play a mom or a wife; nobody ever saw me in that role, which is weird, since that's who I really am. "

" I am a single mom of three girls, and I'm getting through that. If I can get through that, I can direct a whole season of television that I star in. "

" I can't imagine bringing in somebody else to direct my show. Wouldn't that be funny, if next season I had, like, Michael Bay come in and direct 'Better Things'? I wonder what that would be like? "

" You've gotta leave enough space for your actors to bring stuff to the table and whatever the weather's doing that day or what the light's like. Things can shift, and you have to be malleable. Every day is a different feeling and a change. "

" You can't regulate what these kids are being exposed to on the Internet. It's so way out of control. All you can do is just try to talk to your own kids. "

" It's spelled, like, S-E-R-G. I always thought it would be funny if I called my son 'Sir.' Like calling your daughter 'Ma'am,' or something like that. "

" For me, running a set and directing has been the most rewarding thing of my life and a happy surprise, because it was never really on my radar. "

" Sometimes when I'm in the editing room and there's a new person there, like a music editor or a post person that I don't really know, I'm like, 'Oh, you shouldn't be in here. This is too personal - you can't watch this.' But then I'm like, hey dummy, you're about to show this to the whole world. "

" I want to elevate the mundane. "

" Everybody hates you when you're the best, and everybody hates you when you're the worst. "

" I've always been interested in how other people live their lives, which is why it's important to engage fully even in painful times. And out of that, I get to laugh. "

" The first thing that I ever made was a documentary that I shot... in downtown L.A. about a group of homeless people. "