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" For me, running a set and directing has been the most rewarding thing of my life and a happy surprise, because it was never really on my radar. "

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" I want to create opportunities for women, of course. "

" They would call me 'The Cleaner' because I would replace boys who were real adolescents, and their voices completely changed, and they couldn't do the voices anymore. "

" Everything that happens to me in a day enhances my parenting. "

" I don't usually say 'working mom' because I think all moms are working moms. I feel like that diminishes moms. People should say 'working dad' as opposed to working moms. "

" Sometimes when I'm in the editing room and there's a new person there, like a music editor or a post person that I don't really know, I'm like, 'Oh, you shouldn't be in here. This is too personal - you can't watch this.' But then I'm like, hey dummy, you're about to show this to the whole world. "

" I never want to waste a frame. I always look and see what I've got. "

" The first thing that I ever made was a documentary that I shot... in downtown L.A. about a group of homeless people. "

" I'm trying to keep my days very efficient, and I keep my set really tight. Every single corner is active, and everybody gets to thrive in the job that they do. I don't waste people's time. "

" I want to be a strong, safe mom who my kids also want to be around. "

" I took my daughters to see Plastic Ono Band at the Orpheum in L.A. in 2012. It was an amazing experience because she is such a revolutionary artist. Everybody was like, 'Oh, it's Yoko, it's such a joke.' But it's no joke what she did, visually and musically. It's incredible. "

" It's a hilarious part of my past, all the sitcoms I did in the '80s. And then all the animation - animation is amazing. It's really been great. "

" My life is extraordinary because it's so normal, but it's so 'extra' for some reason. "

" Wouldn't it be funny if I were a total nightmare? If I just shot 21-hour days and went over budget? But, you know, it's something I'm really careful about, because I am a mom, and also, I'm an actor. I'm a pleaser: I don't want to take up too much of people's time. "

" I've been working since I'm 9 years old. "

" There's something in my voice tonally that's like a boy, so I started being able to do boy voices and to be known as having a naturalistic boy tone without pushing it. "

" One of the things I learned in animation is that you never, ever want to start doing a voice that you can't sustain for four straight hours. "

" When I saw 'Louie' and 'Girls', I was blown out of the water. They were fearless portrayals of real life. Everyone has a different experience. "

" Before 'Lucky Louie,' nobody would ever cast me to play a mom or a wife; nobody ever saw me in that role, which is weird, since that's who I really am. "

" I always tell young people when I'm trying to encourage them, 'You have certain windows in your life, and you have to take advantage of it. You gotta jump through because they will shut on you.' "

" The thing about women playing boys is that we're not going to age, and we're not going to go through puberty in the middle of a long-running series. "

" When you hit your 40s, you're walking around, and you realize, 'Oh, my God, men don't look at me anymore.' Or sometimes you can feel really good, and then you look in the mirror, and you're like, 'Oh, Jesus, that's my face now!' But I have tell you that something happened and shifted inside of me. "

" Being a mother is the ultimate training ground for anything. "

" My roles in the '80s were, like, gender dysphoric. I wasn't pretty, I wasn't this, I wasn't that. And I am kind of butchy, you know. That's just my thing. "

" I can't imagine bringing in somebody else to direct my show. Wouldn't that be funny, if next season I had, like, Michael Bay come in and direct 'Better Things'? I wonder what that would be like? "

" I like people to have their own reaction and their own take on things. And I don't like to shove my - what I want them to feel or think - down their throats. I like people to say, 'What was that about?' or 'Why did that happen?' And so, any reactions are welcome. "

" I've always been kind of a mom. I was out of my house when I was 18, and my friends used to call me 'mother' and 'care unit.' "

" It's spelled, like, S-E-R-G. I always thought it would be funny if I called my son 'Sir.' Like calling your daughter 'Ma'am,' or something like that. "

" I've been adapting ever since my oldest had her first play date with a boy, and I was like, 'That's not normal,' because I came from the old school. Now boys sleep over at my house. It doesn't matter which girl, which age. "

" You can't regulate what these kids are being exposed to on the Internet. It's so way out of control. All you can do is just try to talk to your own kids. "

" You can go in and out of love and still love somebody, you know? You may not like them so much on the day, but I can tell you that I don't think I've ever been so vulnerable or been so angry in my life - like, those two emotions feel so hurt or so enraged - as when you're dealing with your kids. "