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" I believe the biggest breakthroughs on cancer could come from brilliant researchers based in India. "
Siddhartha Mukherjee
I Believe
Cancer
India
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" What we do in the laboratory is we try to design drugs that will not just eradicate cancer cells but will eradicate their homes. "
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" In a spiritual sense, a positive attitude may help you get through chemotherapy and surgery and radiation and what have you. But a positive mental attitude does not cure cancer - any more than a negative mental attitude causes cancer. "
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" Writing anything as an expert is really poisonous to the writing process, because you lose the quality of discovery. "
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" Unlike other diseases, the vulnerability to cancer lies in ourselves. We always thought of disease as exogenous, but research into cancer has turned that idea on its head - as long as we live, grow, age, there will be cancer. "
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" Postwar U.S. was the world's leader in science and technology. The investment in science research was staggering. "
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" There is a very moving and ancient connection between cancer and depression. "
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" We now have poured in an enormous amount of resources into cancer. The National Cancer Institute Project, you know, runs about $5 billion a year. That's a large amount of money, but let's not be grandiose about the amount of money we're actually spending on a problem that is attacking us at the most fundamental level of the human species. "
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" Because I work on leukemia, the image of cancer I carry in my mind is that of blood. I imagine that doctors who work on breast cancer or pancreatic cancer have very different visualizations. "
Siddhartha Mukherjee
Blood
Work
Cancer
" I think when we use 'stress', we are often using a kind of dummy word to try to fit many different things into one big category. "
Siddhartha Mukherjee
Stress
Kind
Think
" Some cancers are curable, while others are highly incurable. The spectrum is enormous. Metastatic pancreatic cancer is a highly incurable disease, whereas some leukemia forms are very curable. There is a big difference between one form and another. "
Siddhartha Mukherjee
Cancer
Big
Difference
" Most discoveries even today are a combination of serendipity and of searching. "
Siddhartha Mukherjee
Searching
Serendipity
Today
" There's a rising cancer trend and, as I said, one of the major contributors is the overall ageing of the population - we aren't dying of other things, so we're dying of cancer. "
Siddhartha Mukherjee
Things
Dying
Trend
" There is a duality in recognising what an incredible disease it is - in terms of its origin, that it emerges out of a normal cell. It's a reminder of what a wonderful thing a normal cell is. In a very cold, scientific sense, I think a cancer cell is a kind of biological marvel. "
Siddhartha Mukherjee
Sense
Normal
Cold
" The history is important because science is a discipline deeply immersed in history. In other words, every time you perform an experiment in science or in medicine, what you're actually doing is you're answering someone, answering a question raised by someone in the past. "
Siddhartha Mukherjee
History
Science
Past
" Sidney Farber was a pathologist. He was called a doctor of the dead. He was a pathologist who sort of lived in the basement of the children's hospital in Boston, and he became very interested in childhood leukemia. And Farber began to inject this drug, aminopterin, into young kids, in order to see if he could get a remission. "
Siddhartha Mukherjee
See
Children
Doctor
" Probably the most important reason we are seeing more cancers than before is because the population is ageing overall. And cancer is an age-related disease. "
Siddhartha Mukherjee
Important
Cancer
Seeing
" What does it mean to be an oncologist? It means that you get to sit in at a moment of another person's life that is so hyper-acute, and not just because they're medically ill. It's also a moment of hope and expectation and concern. "
Siddhartha Mukherjee
Life
Just Because
Hope
" One day, I had a patient who was going through chemotherapy who came to me and said, 'I'm going to go on with what I'm doing, but I need you to tell me what it is that I'm fighting.' "
Siddhartha Mukherjee
Day
You
Need
" There is an enormous amount of options that a physician can provide today, right down from curing patients, treating patients, or providing patients with psychic solace or pain relief. So, in fact, the gamut of medical intervention is enormous. "
Siddhartha Mukherjee
Physician
Medical
Down
" I could write a thesis on the physiology of vision. But I had no way to look through the fabric of confabulation spun by a man with severe lung disease who was prescribed 'home oxygen', but gave a false address out of embarrassment because he had no 'home.' "
Siddhartha Mukherjee
Disease
Vision
Way
" If you take 100 breast-cancer samples, 100 types of cancer have 100 different hallmarks of mutated genes. You could be nihilistic and say, 'Oh, God, we'll never be able to tackle this!' But there are deep, systematic, organizational principles at work in all that diversity. "
Siddhartha Mukherjee
Deep
Diversity
God
" Cancer has enormous diversity and behaves differently: it's highly mutable, the evolutionary principles are very complicated and often its capacity to be constantly mystifying comes as a big challenge. "
Siddhartha Mukherjee
Diversity
Cancer
Principles
" When you immerse yourself in medicine you realise that hope is not absolute. It's not that simple. "
Siddhartha Mukherjee
Hope
Yourself
You
" I once set myself a deadline: half a chapter a week, 20 minutes a day. The thought froze me instantly, like literary Botox. I returned to my non-schedule: sleeping, writing 20 minutes, and then back to sleep. Breakfast in bed, with juice congealing on the sill: pages and pages began to pour out again. "
Siddhartha Mukherjee
Sleep
Day
Breakfast
" A breast cancer might turn out to have a close resemblance to a gastric cancer. And this kind of reorganization of cancer in terms of its internal genetic anatomy has really changed the way we treat and approach cancer in general. "
Siddhartha Mukherjee
Way
Treat
Breast Cancer
" Cancer is not just a dividing cell. It's a complex disease: It invades, it metastasizes, it evades the immune system. "
Siddhartha Mukherjee
Disease
Just
System
" Robert Sandler is a child who died when he was three years old, and he is a child who was the first child that we know of to be treated with chemotherapy. "
Siddhartha Mukherjee
Old
Three
Child
" Good physicians are rarely dispassionate. They agonize and self-doubt over patients. "
Siddhartha Mukherjee
Over
Rarely
Self-Doubt
" Cell culture is a little like gardening. You sit and you look at cells, and then you see something and say, 'You know, that doesn't look right'. "
Siddhartha Mukherjee
Look
Say
You
" The trick to my writing, it turned out, was doing so exclusively in bed. The minute I even dared to discipline myself and write at the desk, I produced mounds of nonsense. Yet, sitting in bed, I wrote easily, effortlessly, fluidly. I became the master of perfect indiscipline. "
Siddhartha Mukherjee
Myself
Discipline
Perfect