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" I feel like I'm working on an oil rig right now. I'm away from home a lot. "

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" Ideas are 10 a penny. It's the execution that's the hard thing to do. House is standing up against a tide of sentiment and emotionalism over reason that threatens to engulf this world. When you think about it, a rationalist, a man of science and reason, is in a pretty lonely position. "

" Muddy Waters, I suppose, was my first great hero. You know, every boy wants to be a guitar player, and Muddy Waters was just the king. He was the King Bee. He was it. "

" I don't have a single complete show or movie or anything else that I could look at and say, 'Nailed that one.' But endless dissatisfaction is, I suppose, what gets us out of bed in the morning. "

" You hope that your teenage self would like and forgive your 50-year-old self. "

" I think my father gave me a great reverence for medical science. He was about as opposite to the personality of House as one could imagine. He was polite and easygoing, and would have gone to great lengths to make his patients feel attended to and heard and sympathized with. "

" It's easier for a camel to pass through the eye of a needle than for a rich man to make a blues record. "

" It doesn't rain at all in California. Once a month, a man drives through spraying Evian. "

" In film, because you know where the ending is, characters can change, but in television, you substitute revelation for change, and that can be hard to pull off. "

" I have always stuck up for Western medicine. You can chew all the celery you want, but without antibiotics, three quarters of us would not be here. "

" I never was someone who was at ease with happiness. "

" Piano was - well, all musical instruments were taught in this very rigid, formal, classical method when I was young. "

" I think there is a basic comfort in clever people who know things. "

" The strange thing - and this is one of the advantages of being incredibly shallow and superficial - is that wherever I am, that's sort of home. "

" I admit I can't shake the idea that there is virtue in suffering, that there is a sort of psychic economy, whereby if you embrace success, happiness and comfort, these things have to be paid for. "

" To be a head boy, you have to be very clever, you have to be a scholar, and I was never a scholar in any shape or form. "

" L.A. runs on optimism, enthusiasm and flattery. I think you can go a little bit crazy. I've heard people say there's a limit to the number of years you can stay in this city without going slightly mad. It's just too damn sunny in every dimension - weather-wise, socially and professionally. "

" As a real person, he wouldn't last a minute, would he? But drama is about imperfection. And we've moved away from the aspirational hero. We got tired of it, it was dull. If I was House's friend, I would hate it. How he so resolutely refuses to be happy or take the kind-hearted road. But we don't always like morally good people, do we? "

" I was too shy, I think, to sing publicly. It takes a particular kind of person. And when I was young, I was not that person. In the first instance, when a record company said to me, do you want to try and make your record, my first reaction was, no, I'm not worthy - I couldn't possibly, and so on and so forth. "

" I think pain is a very - it's an extremely hard thing to empathize moment to moment. And you often don't remember your own pain, you know, that moment that you broke a limb or you burned yourself or, I think, this is a common thing that women talk about with childbirth, that the memory of the pain is hard to summon up and relive, thankfully. "

" I personally believe that the iPod is a frankly corrosive device because it encourages you to surround yourself with your favorites. The whole idea of a playlist is to surround yourself with your favorite things, and the interesting thing is that when you do that, they cease to be your favorites. "

Surround Yourself

" I get anxious about a lot of things, that's the trouble. I get anxious about everything. I just can't stop thinking about things all the time. And here's the really destructive part - it's always retrospective. I waste time thinking of what I should have said or done. "

" Driving a motorcycle is like flying. All your senses are alive. When I ride through Beverly Hills in the early morning, and all the sprinklers have turned off, the scents that wash over me are just heavenly. Being House is like flying, too. You're free of the gravity of what people think. "

" I never thought I'd end up living in Los Angeles while my children grew up in Britain, but here I am, and we are all making the best of it. "

" Music is one of the noblest callings I can think of. It's the highest of all the art forms to me. For example, if my kid said to me, 'I want to give it all up,' whatever it is that they're doing, 'and I want to take my saxophone and go out,' I would say, 'May God go with you. This is a great and noble thing that you're doing.' "

" I think good-looking people seldom make good television. And American television studios almost concede before they start: 'Well, it won't be good, but at least it'll be good-looking. We'll have nice-looking girls in tight shirts with F.B.I. badges and fit-looking guys with lots of hair gel vaulting over things.' "

" I'm reasonably easygoing. Messing up my lines or making a fool of myself is where you find my fears. Like a lot of English people, I'm prey to embarrassment - the dread that everyone's sort of sniggering at you, that you're going to look like an idiot. I think that sort of halts us all. "

" I feel like a hostage to fortune. Not that I am complaining. I wanted to play the role. But in truth I didn't think the show would be such a success. OK, I thought it would fail. Not because it was bad. I was confident it was good, but plenty of good things just sort of wither on the vine. "

" The first big stars, Bessie Smith, Ma Rainey, you know, these were gigantic stars. I even wonder sometimes whether all music actually comes from women, whether the first glimmering of music is a mother soothing a baby. "

" I don't like the act of talking; it makes me slightly light-headed. "

" I have been instrumental in banning bottled water on the set. It hasn't gone that well with the crew... so I replaced it with tequila. "