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" I never want to waste a frame. I always look and see what I've got. "

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" There's something in my voice tonally that's like a boy, so I started being able to do boy voices and to be known as having a naturalistic boy tone without pushing it. "

" Everybody hates you when you're the best, and everybody hates you when you're the worst. "

" I always tell young people when I'm trying to encourage them, 'You have certain windows in your life, and you have to take advantage of it. You gotta jump through because they will shut on you.' "

" I learned so much from the writing on 'King of the Hill', which I thought was just magnificent. They would let real moments happen in this animated, one-dimensional world. I feel like I've been in school this whole time. "

" You can go in and out of love and still love somebody, you know? You may not like them so much on the day, but I can tell you that I don't think I've ever been so vulnerable or been so angry in my life - like, those two emotions feel so hurt or so enraged - as when you're dealing with your kids. "

" The thing about women playing boys is that we're not going to age, and we're not going to go through puberty in the middle of a long-running series. "

" Sometimes when I'm in the editing room and there's a new person there, like a music editor or a post person that I don't really know, I'm like, 'Oh, you shouldn't be in here. This is too personal - you can't watch this.' But then I'm like, hey dummy, you're about to show this to the whole world. "

" Wouldn't it be funny if I were a total nightmare? If I just shot 21-hour days and went over budget? But, you know, it's something I'm really careful about, because I am a mom, and also, I'm an actor. I'm a pleaser: I don't want to take up too much of people's time. "

" I don't think I have a demographic. I was at Comic-Con in San Diego recently, and I was doing a signing, and my line was all military guys, young girls, housewives and guys in wheelchairs. There was just everybody all over the place. "

" My roles in the '80s were, like, gender dysphoric. I wasn't pretty, I wasn't this, I wasn't that. And I am kind of butchy, you know. That's just my thing. "

" Literally, FX is like, 'How can we foster your vision?' My vision is pretty much taking pictures of the way I see my life. "

" Cooking is the best occupational therapy for me. And when I cook, everybody comes to eat. It's the greatest thing. "

" I just like to keep things small and subtle and authentic, and ground everything in reality. So that is something that I feel is my strength as a director and I try to achieve as an actor. "

" I don't usually say 'working mom' because I think all moms are working moms. I feel like that diminishes moms. People should say 'working dad' as opposed to working moms. "

" I've always been kind of a mom. I was out of my house when I was 18, and my friends used to call me 'mother' and 'care unit.' "

" I love that, 'mommy-shaming.' When I was a new mom, I was obsessed with how I was being perceived and trying to fit in as a mom, going to mommy-and-me classes and things like that, and never quite measuring up to 'the real moms,' the 'robot moms,' as I called them. "

" My life is extraordinary because it's so normal, but it's so 'extra' for some reason. "

" I went from buying my own condominium and a car for myself when I was 17 on 'The Facts of Life' to not being able to pay my rent. I was at the unemployment office all the time. I had to sell my record collection just to make ends meet. And then I started getting these voice-over jobs. "

" I like people to have their own reaction and their own take on things. And I don't like to shove my - what I want them to feel or think - down their throats. I like people to say, 'What was that about?' or 'Why did that happen?' And so, any reactions are welcome. "

" 'Roseanne' was massive for me. I adored that show. I mean, the show was this couple who weren't cookie-cutter, and they were sexy, and we know that they like to have sex with each other, and they flirted, and then they ragged on their kids, and their kids ragged on them, and it was such a realistic depiction. "

" I don't like to let people know where I'm going to end up, and I don't personally like to know where I'm going. "

" If I'm doing a voice-over session, like animation or something, and I'm doing three different voices, you've gotta separate them. You've gotta find the different places and do your different things. "

" It's spelled, like, S-E-R-G. I always thought it would be funny if I called my son 'Sir.' Like calling your daughter 'Ma'am,' or something like that. "

" For me, running a set and directing has been the most rewarding thing of my life and a happy surprise, because it was never really on my radar. "

" It's a hilarious part of my past, all the sitcoms I did in the '80s. And then all the animation - animation is amazing. It's really been great. "

" Before 'Lucky Louie,' nobody would ever cast me to play a mom or a wife; nobody ever saw me in that role, which is weird, since that's who I really am. "

" I try to direct myself the way I direct the other actors who come on my show. "

" I get up at 6 A.M., and sometimes I make lunch for my two youngest kids. Usually my oldest sleeps late, and I get my kids out the door to school. For years, it was me just doing all of that and then driving to a carpool or this or that. "

" The first thing that I ever made was a documentary that I shot... in downtown L.A. about a group of homeless people. "

" I've been working since I'm 9 years old. "