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" Karen is like RuPaul - she's a character. It never occurred to me until now, but she is! "

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" I certainly have gay friends, but I don't remember thinking, 'Oh my God, I have this friend, and they're gay, and that's so cool.' I mean, I was very naive until I got to a certain age. "

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" John Cleese was my personal favorite because he played my husband for a whole season - and Minnie Driver. We almost had our own, like, show all living in a house together. And Gene Wilder was just so dear. "

" Now, it's weird not to have gay characters on a show. "

" Nick's just from this very Norman Rockwell-ish family. They're very 'American Gothic,' and his parents are so kind, and they're not brash people; they're very soft spoken, salt of the earth. "

" My mom is elderly, and she's not doing too well, and I've literally never told her about 'Childrens Hospital,' because I fear that if she ever sees it, it will be like the coup de grace. "

" I married the reigning mustache champion. "

" I tend to let the chips fall where they may. I don't know if that's right or wrong. "

" The ratio of celebrity divorces is probably about the same as non-celebrity divorces; it's just that the non-celebrity divorces don't get a lot of public scrutiny, normally. "

" All the writers on our show went in and got in the bed and took a picture in Cher's bed, even though she was never in it. "

" A lot of people are saying it's an inspiration to see a couple who are in love and getting a kick out of each other. "

" I feel like Nick and I have the best relationship and the best marriage. "

" All I know is Karen is besties with Donny and Melania. "

" I started 'Will & Grace' when I was 39, and Nick started 'Parks and Rec' when he was 39. And he's really on the same trajectory; it's all happening with the same timing. It's so funny to see it all happening again. "

" Karen will never die. Max Mutchnick, one of the creators of the show, has always maintained that Karen is a bat who balls up and hangs from a rafter and sleeps during the day and that she'll live forever. "

" I can understand everybody associates me with Karen, but beyond that, I think after time passes and a few years go by, that sort of becomes a non-issue. That character is far - I mean really, all the characters I've played are pretty far away from what I'm really like. "

" One year at the SAG Awards, somebody practically knocked me over, and it was Helen Mirren. She was like, 'Oh my God - is it really you? I'm your biggest fan.' I was like, 'Wait, aren't you supposed to be home reading Shakespeare or something?' "

" Isn't that sort of what happened with gay marriage? Right before gay marriage was legalized, everybody was just losing their minds and, like, the worst possible things were happening, and it was just all like it couldn't get any worse, and then it suddenly got a lot better. "

" Why can't I ever play a nice, normal, salt-of-the-earth type? Is there something I should know? It's fun to play villains and character roles, of course - but I'm sure it's also fun to be a really big star and play the lead in everything, where all you have to do is show up and not blink. "

" Nick has said he would divorce me if I got Botox. "

" Karen was always such a lawless rebel: carrying a gun in her purse, flirting with 14-year-old boys. She's the worst. You know that horrible guy Milo Yiannopoulos? She has about as many redeeming qualities as he has. "

" Nick gets carsick if he's not driving - plus, he's basically a walking atlas. He can drive around any city without a map, which works out fine for me because I just become our entertainment director and pick out which audio book we'll listen to next. "

" We have a two-week rule. We're never apart for more two weeks. Just not being separated for Jurassic periods of time seems to help. And no children probably helps a lot. "

" Sean is so funny. One time he went to Ireland for two weeks with his mother, and Ireland is so beautiful, and he got back; we were like, 'How was it?' and he was like, 'Ugh I was so bored.' "

" If we're ever seen having a public spat in a coffee shop, I think the concept of romance will die. "

" I get deep into the creative aspect, and Nick is the people person. "

" Nick was cast first in both 'Smashed' and 'Kings.' "

" He is not like Ron Swanson at all because he's very emotional and vulnerable. He is all of the things that I guess Ron was really deep down. He's not a Libertarian, but he does like bacon and meat. "

" It's funny when you follow your own sort of bliss, then other people tend to respond in kind, meaning audiences. It's really weird how that works, but it does seem to apply to 'Nancy & Beth' especially. "

" I never had a burning desire to have children. But then I met Nick, and I thought, 'This is the only person I'd do this with.' So we tried, but I was a little long in the tooth for that sort of thing. But we didn't turn it into a soap opera. We tried for about a year or so, and it didn't happen and took that to mean it wasn't meant to be. "