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" Nick was cast first in both 'Smashed' and 'Kings.' "

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" Nick can get up on stage and just wing it, whereas I would have to be taken to a mental institution. "

" People are always flabbergasted, like, 'You sing?' "

" Playing Karen was so satisfying that it almost cured my acting bug completely. Not that I had conquered the world of acting. It was just that I had something to prove to myself when I started Will & Grace. Now I feel like, okay, well, I've satisfied that. "

" All I know is Karen is besties with Donny and Melania. "

" My mom is elderly, and she's not doing too well, and I've literally never told her about 'Childrens Hospital,' because I fear that if she ever sees it, it will be like the coup de grace. "

" Karen will never die. Max Mutchnick, one of the creators of the show, has always maintained that Karen is a bat who balls up and hangs from a rafter and sleeps during the day and that she'll live forever. "

" He proposed, in London, in 2002. "

" Karen is like RuPaul - she's a character. It never occurred to me until now, but she is! "

" I'm a big hit with guards at security. They're the center of my fan base, the airport security guards. "

" I can understand everybody associates me with Karen, but beyond that, I think after time passes and a few years go by, that sort of becomes a non-issue. That character is far - I mean really, all the characters I've played are pretty far away from what I'm really like. "

" I think theater is more about living and breathing, versus TV, which can vary. "

" If we're ever seen having a public spat in a coffee shop, I think the concept of romance will die. "

" I love creating new characters that are whatever they are. "

" People who have theater or sketch-comedy backgrounds seem to be more, you know, our speed. Like Amy Poehler and Will Arnett - we double date. "

" One year at the SAG Awards, somebody practically knocked me over, and it was Helen Mirren. She was like, 'Oh my God - is it really you? I'm your biggest fan.' I was like, 'Wait, aren't you supposed to be home reading Shakespeare or something?' "

" Now, it's weird not to have gay characters on a show. "

" Madonna was very cool. I thought she was really nice, really present, and she worked really, really hard... She didn't necessarily know our real names in real-life, because why should she? Who cares? Some of the cast were really offended, like, 'She doesn't even know my name!' I'm like, 'Who cares? Madonna's doing our show. It doesn't matter.' "

" I never had a burning desire to have children. But then I met Nick, and I thought, 'This is the only person I'd do this with.' So we tried, but I was a little long in the tooth for that sort of thing. But we didn't turn it into a soap opera. We tried for about a year or so, and it didn't happen and took that to mean it wasn't meant to be. "

" You can really shoot things you think might work on camera one way, then you can try it that way, and then if you think it could also work another way, you have that luxury of shooting a bunch of different steps, and then they can decide in editing what works the best. "

" John Cleese was my personal favorite because he played my husband for a whole season - and Minnie Driver. We almost had our own, like, show all living in a house together. And Gene Wilder was just so dear. "

" I think a lot of actors, maybe who have been on a hit show and been lucky enough to get successful, might say 'no' more than I do. And maybe that's good, maybe that's smart. I don't know. "

" I always thought, 'Oh, Cher seems so cool. If I ever met her, I know we'd be best friends.' "

" I like to work. I mean, part of it for me is that I was a struggling actor, could barely pay my rent, until I was almost 40. "

" All the writers on our show went in and got in the bed and took a picture in Cher's bed, even though she was never in it. "

" I had a lot of friends for a long time who were gay, and I didn't even realize it for awhile. Even in my mid- to late 20s, I was still pretty naive about it. "

" Isn't that sort of what happened with gay marriage? Right before gay marriage was legalized, everybody was just losing their minds and, like, the worst possible things were happening, and it was just all like it couldn't get any worse, and then it suddenly got a lot better. "

" You should definitely stay true to your own style. "

" I get deep into the creative aspect, and Nick is the people person. "

" I love Chicago - absolutely love Chicago. I mean, I'd much rather go to Chicago and do a play or a musical than New York, honestly. Because just probably for reasons that are obvious to you. It's just a little bit - it's a nicer, easier city. "

" During 'Will & Grace,' we had so many things we had to go to where you get all dolled up. It's like pulling teeth for me. "