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" Your genetics is not your destiny. "
George M. Church
Genetics
Your
Destiny
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" I like to keep the median age in my lab low because they will indulge me in my dreams. They don't yet think things are impossible. "
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" We have a love affair with the idea of the 'natural,' even though we, as a species, are about as unnatural as you can imagine. "
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" The rewards for biotechnology are tremendous - to solve disease, eliminate poverty, age gracefully. It sounds so much cooler than Facebook. "
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" Someone younger at heart should replace you, and that should be you. I'm willing to. I'm willing to become younger. I try to reinvent myself every few years anyway. "
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" A few dozen changes to the genome of a modern elephant - to give it subcutaneous fat, woolly hair and sebaceous glands - might suffice to create a variation that is functionally similar to the mammoth. Returning this keystone species to the tundras could stave off some effects of warming. "
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" There's a lot of faith expressed by scientists about science. It's kind of an act of faith that science is a good thing. We don't know that for sure. We may not know that millions of years from now. "
George M. Church
Know
Good
Now
" Most groups patent ways of using genetic discoveries as part of non-obvious diagnostic and therapeutic protocols and slightly or greatly altered genes. "
George M. Church
Most
Genetic
Ways
" We will have to make a decision, as we go into new environments outside of earth, whether we want to drag along with us all our pathogens. We can, or we can't - it's up to us - but I consider that part of genome engineering is how we interact with the huge part of our genome which is our microbiome. "
George M. Church
Want
Earth
Engineering
" I am 3.8 percent Neanderthal. One of my ancestors mated with a Neanderthal, and I am not embarrassed by that. "
George M. Church
Embarrassed
I Am
Percent
" Reversal of ageing is high on my list of things to do, and not just because I'm getting old. "
George M. Church
Old
Getting Old
High
" If you get a personal genome, you should be able to get personal cell lines, stem cell derived from your adult tissues, that allow you to bring together synthetic biology and the sequencing so that you can repair parts of your body as you age or repair things that were inherited disorders. "
George M. Church
Bring
You
Together
" Most people are excited about themselves. Personal genome will deliver for inexpensively something about science to which you can relate. Just like computers are becoming something to which you can relate. It should be even easier to relate to your own biology, and I hope that will be one of the ways we get broader literacy in science. "
George M. Church
Computers
Science
People
" What I really wanted was for everybody to have their genome and, ideally, everybody to share their genome, and for that, we needed to bring the price way down. "
George M. Church
Share
Down
Genome
" I'm a champion for personal differences. I have no sympathy for drug companies that can't figure out how to make personalized medicine. We could generalize that to 'All society should be much more personalized.' "
George M. Church
Society
Champion
Medicine
" We have the ability to completely change our environment to go... to take on... to inherit, in a certain sense, things far beyond our DNA, and that's inheritable. And we can see evolution in action as our ideas evolve and undergo a kind of Darwinian selection not at the DNA level. And we can go off into space. "
George M. Church
Action
Evolution
Space
" Letting the tundra melt is the equivalent to burning all of the forests in all of the world and their roots two and a half times over. "
George M. Church
Roots
Two
World
" Every cell in our body, whether it's a bacterial cell or a human cell, has a genome. You can extract that genome - it's kind of like a linear tape - and you can read it by a variety of methods. Similarly, like a string of letters that you can read, you can also change it. You can write, you can edit it, and then you can put it back in the cell. "
George M. Church
You
Back
Human
" You can make pigs that are essentially much closer to being universal donors. If it works, their organs will be going into people like you and me. "
George M. Church
Like
Me
Going
" If we go into space, we need enhancements that handle radiation and osteoporosis... or else we're dead. So what seems like an enhancement in one generation becomes life and death in another generation. "
George M. Church
Need
Death
Space
" My laboratory and my obsession is about safety and building/engineering safety. It's not just a matter of saying we want the world to be safer; we have to create technology. "
George M. Church
Technology
World
Safety
" As part of our dedication to safety engineering in biology, we're trying to get better at creating physically contained test systems to develop something that eventually will be so biologically contained that we won't need physical containment anymore. "
George M. Church
Test
Trying
Better
" We might want to figure out what are the positive effects of autism - mild cases. "
George M. Church
Autism
Figure
Out
" It sounds a little bit too arrogant, but I think I certainly have a working model for how I conduct my life, and it may or may not be a correct worldview. "
George M. Church
My Life
Think
Working
" I think my original inspiration came from just natural curiosity about science and math and biology. In particular, I would say that, as I matured, it became more a feeling of trying to avoid the waste that occurs in the world where we have 6.5 billion minds. If you're a computer scientist, you can think of them as supercomputers. "
George M. Church
Think
Science
Curiosity
" I will make the argument that we are poorly adapted to our current environment. I mean, we did not evolve to sit all day and be exposed to giant amounts of really tasty food. "
George M. Church
Day
Argument
Environment
" The one thing that is bad for society is low diversity. If you become a monoculture, you are at great risk of perishing. Therefore, the recreation of Neanderthals would be mainly a question of societal risk avoidance. "
George M. Church
Diversity
Great
Risk
" There's this very interesting and complicated connection between our environment and our genes and the traits that come out of the environment plus genes. And there's huge potential. I mean we see amazing abilities. Marie Curie, Albert Einstein. All sorts of arts, and literature and so forth. These are not typical traits of everybody on earth. "
George M. Church
Amazing
Earth
Environment
" I'll drop something for a while, a year or maybe several years, and then pick it up again. I think that's the way successful innovators work. They keep juggling ideas, keeping them in the air, in the back of their mind, to inspire them or enable new recombinations. "
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Work
Back
Think
" The goal of reanimation research is not to make perfect living copies of extinct organisms, nor is it meant to be a one-off stunt in a laboratory or zoo. Reanimation is about leveraging the best of ancient and synthetic DNA. "
George M. Church
Goal
Best
Living
" The goal of getting your genome done is not to tell you what you will die from, but it's how to learn how to take action to prevent disease. "
George M. Church
Done
Goal
Learn