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" I was using very unconventional methods to sequence the telemetric DNA, originally. "

Elizabeth Blackburn

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" Cancer cells have had so many other things go wrong with them, genetic, non-genetic changes, that those cells, one of the things they then get selected for is that they have lots of telomerase because now the telomeres in those cells get maintained. "

Elizabeth Blackburn

" Being senior enough in the field, having enough solidity, I don't feel afraid of being marginalized. "

Elizabeth Blackburn

" In my lab, we're finding that psychological stress actually ages cells, which can be seen when you measure the wearing down of the tips of the chromosomes, those telomeres. "

Elizabeth Blackburn

" We and other groups are seeing clear statistical links between telomere shortness and risk for a variety of diseases that are becoming very common, such as cardiovascular disease, diabetes and certain cancers. "

Elizabeth Blackburn

" At Cambridge, there was a completely unintimidating culture, and there were no class divisions among the students. "

Elizabeth Blackburn

" I'm pretty good about getting some exercise every day - well, most days. The secret for me was to put the elliptical in front of the TV. "

Elizabeth Blackburn

" If we think of our chromosomes - they carry our genetic material - as being like shoelaces, I work on the plastic tips at the end that protect them. "

Elizabeth Blackburn

" As maize became important for human food worldwide, modern agricultural research on maize breeding continued the corn breeding begun thousands of years ago in the Central American highlands. "

Elizabeth Blackburn

" This enzyme, called telomerase, slows the rate at which telomeres degrade, and research indicates that healthy people with longer telomeres have less risk of developing the common illnesses of aging - like heart disease, diabetes, and cancer, which are three big killers today. "

Elizabeth Blackburn

" When scientists get old, they get interested in the brain, and I'm a little bit afraid I'm falling into that. "

Elizabeth Blackburn

" Studying organisms at a molecular level was totally compelling because it was moving from being a naturalist, which was the 19th-century kind of science, to being very focused and really getting to the heart of these molecules. "

Elizabeth Blackburn

" Observational studies show that exercise, nutritional supplements and reducing psychological stress can help. Chronic high stress and smoking can lead to accelerated telomere shortening. "

Elizabeth Blackburn

" When you bring telomerase RNA levels down by using a mechanism that targets the RNA for destruction, the cells which were running on very high telomerase levels are now running on a lean diet of telomerase. "

Elizabeth Blackburn

" Medicine has been successful by treating diseases in a very specific way once the damage is done. But telomere length integrates a lot of factors together and gives you an overall picture of risk for what is now emerging as a lot of diseases that tend to occur together, such as diabetes and heart disease. "

Elizabeth Blackburn

" In my early work, our molecular views of telomeres were first focused on the DNA. "

Elizabeth Blackburn

" Ageing is so many different things, and cells being able to self-renew is part of the picture but not all of it. "

Elizabeth Blackburn

" For me, arguably the story of telomeres and telomerase began thousands of years ago, in the cornfields of the Maya highlands of Central America. "

Elizabeth Blackburn

" Generally, we try to have a situation where the person is healthy, so you're not confounded by disease. So, that means that healthy individuals are donating their blood samples for the studies. "

Elizabeth Blackburn

" The goal is to learn more about telomere length and other markers of ageing, how best to measure these markers, how they are related to health and lifestyle, and how people respond to learning their own telomere length results. "

Elizabeth Blackburn

" In the 1970s, I did a Ph.D. with Fred Sanger in Cambridge who was in the process of inventing ways to map what's inside DNA. He later won the Nobel Prize. "

Elizabeth Blackburn

" In 2004, results from a study that I worked on with colleagues at the University of California, San Francisco, linked chronic stress to shortening of telomeres. "

Elizabeth Blackburn

" Challenges in medicine are moving from 'Treat the symptoms after the house is on fire' to 'Can we preserve the house intact?' "

Elizabeth Blackburn

" Tracing the beginnings of the interwoven stories of science can be arbitrary, as beginnings are so often lost in the mists of time. "

Elizabeth Blackburn

" Telomeres are the protective caps at the ends of chromosomes in cells. Chromosomes carry the genetic information. Telomeres are buffers. They are like the tips of shoelaces. If you lose the tips, the ends start fraying. "

Elizabeth Blackburn

" I spent my first 4 years living in the tiny town of Snug, by the sea near Hobart. Curious about animals, I would pick up ants in our backyard and jellyfish on the beach. "

Elizabeth Blackburn

" Biology sometimes reveals its fundamental principles through what may seem at first to be arcane and bizarre. "

Elizabeth Blackburn

" The most dangerous cancer cells are actually the ones that are more like stem cells, which have this ability to produce themselves over and over again. More and more cancer biologists say stem-cell-like cells in cancers are the most dangerous. "

Elizabeth Blackburn

" Basically, when you look at different types of cells, such as fibroblasts, which form connective tissue, or epithelial cells, from saliva, you see general correlations within a person. If telomeres are up for one cell type, they're up for others overall. "

Elizabeth Blackburn

" Exercise mitigates the effects of stress - and stress, we know, shortens telomeres. In fact, early studies indicate that stress reduction techniques like meditation help people maintain the length of their telomeres. "

Elizabeth Blackburn

" No one ever said, 'Be a doctor.' But because so many members of my extended family - aunts, uncles - were doctors, there was this expectation that I'd probably be a physician. "

Elizabeth Blackburn