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All Quotes by author - Elizabeth Blackburn
" Ageing is so many different things, and cells being able to self-renew is part of the picture but not all of it. "
Different
Picture
Being
" As maize became important for human food worldwide, modern agricultural research on maize breeding continued the corn breeding begun thousands of years ago in the Central American highlands. "
Food
American
Research
" At Cambridge, there was a completely unintimidating culture, and there were no class divisions among the students. "
Culture
Cambridge
Students
" Basically, when you look at different types of cells, such as fibroblasts, which form connective tissue, or epithelial cells, from saliva, you see general correlations within a person. If telomeres are up for one cell type, they're up for others overall. "
Person
You
See
" Being senior enough in the field, having enough solidity, I don't feel afraid of being marginalized. "
Feel
Afraid
Enough
" Biology sometimes reveals its fundamental principles through what may seem at first to be arcane and bizarre. "
Biology
Through
Sometimes
" Cancer cells have a lot of other things that are really wrong with them, and we should never forget that these are cells that have become deaf to all the signals that the body sends out, such as you can multiply a certain amount, you can be in a certain place in the body, where to stay, where to move, and so on. "
Deaf
Never Forget
Place
" Cancer cells have had so many other things go wrong with them, genetic, non-genetic changes, that those cells, one of the things they then get selected for is that they have lots of telomerase because now the telomeres in those cells get maintained. "
Now
Cells
Go
" Challenges in medicine are moving from 'Treat the symptoms after the house is on fire' to 'Can we preserve the house intact?' "
Moving
Fire
House
" Checking your telomere length is a bit like weighing yourself: you get this single number which depends on a lot of factors. Telomere length gives a sense of your underlying health. "
Get
Like
Health
" Exercise mitigates the effects of stress - and stress, we know, shortens telomeres. In fact, early studies indicate that stress reduction techniques like meditation help people maintain the length of their telomeres. "
Stress
Exercise
Help
" For me, arguably the story of telomeres and telomerase began thousands of years ago, in the cornfields of the Maya highlands of Central America. "
Years
Story
Me
" Generally, we try to have a situation where the person is healthy, so you're not confounded by disease. So, that means that healthy individuals are donating their blood samples for the studies. "
Healthy
Blood
Try
" I chose biochemistry as my major and graduated after 4 years with an Honours degree in Biochemistry. During that time, I had come to love biochemistry research, although I was just getting my feet wet in laboratory research. "
Years
Research
Feet
" I decided I wanted to go to Cambridge, and then I got introduced to Fred Sanger. I was very conscientious, and I asked him when I first got there if I should start reading up on things. But he said, 'No, I think you can just start these experiments,' so I plunged right in. "
Said
Reading
Right
" If a test showed you had telomere shortening, it would be a red flag suggesting you should take a look at possible risk factors. "
Red
Risk
Test
" If we think of our chromosomes - they carry our genetic material - as being like shoelaces, I work on the plastic tips at the end that protect them. "
Think
Plastic
Work
" I'm pretty good about getting some exercise every day - well, most days. The secret for me was to put the elliptical in front of the TV. "
Day
Me
Exercise
" In 2004, results from a study that I worked on with colleagues at the University of California, San Francisco, linked chronic stress to shortening of telomeres. "
Colleagues
California
Results
" In humans, the thing is that as we mature, our telomeres slowly wear down. So the question has always been: 'Did that matter?' Well, more and more, it seems like it matters. "
Down
Always
Mature
" In my early work, our molecular views of telomeres were first focused on the DNA. "
DNA
Early
First
" In my lab, we're finding that psychological stress actually ages cells, which can be seen when you measure the wearing down of the tips of the chromosomes, those telomeres. "
Finding
Down
You
" In the 1970s, I did a Ph.D. with Fred Sanger in Cambridge who was in the process of inventing ways to map what's inside DNA. He later won the Nobel Prize. "
Process
Nobel Prize
Map
" I spent my first 4 years living in the tiny town of Snug, by the sea near Hobart. Curious about animals, I would pick up ants in our backyard and jellyfish on the beach. "
Curious
Animals
Living
" I've only actively promoted what we always hope is good science. "
Good
Always
Hope
" I was born in the small city of Hobart in Tasmania, Australia, in 1948. My parents were family physicians. My grandfather and great grandfather on my mother's side were geologists. "
City
Mother
Parents
" I was using very unconventional methods to sequence the telemetric DNA, originally. "
Unconventional
DNA
Methods
" Medicine has been successful by treating diseases in a very specific way once the damage is done. But telomere length integrates a lot of factors together and gives you an overall picture of risk for what is now emerging as a lot of diseases that tend to occur together, such as diabetes and heart disease. "
Together
You
Picture
" No one ever said, 'Be a doctor.' But because so many members of my extended family - aunts, uncles - were doctors, there was this expectation that I'd probably be a physician. "
Because
Doctor
Family
" Observational studies show that exercise, nutritional supplements and reducing psychological stress can help. Chronic high stress and smoking can lead to accelerated telomere shortening. "
High
Help
Exercise
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