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" Nobody's ever kept their sitcom character going after the show's off the air. "

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" There's sacrificing for your art, and then there's just being dumb. "

" I typed up a long email with different band name ideas and sent it to Stephanie, and they all started with 'the'. "

" Why can't I ever play a nice, normal, salt-of-the-earth type? Is there something I should know? It's fun to play villains and character roles, of course - but I'm sure it's also fun to be a really big star and play the lead in everything, where all you have to do is show up and not blink. "

" My mom is elderly, and she's not doing too well, and I've literally never told her about 'Childrens Hospital,' because I fear that if she ever sees it, it will be like the coup de grace. "

" Madonna was very cool. I thought she was really nice, really present, and she worked really, really hard... She didn't necessarily know our real names in real-life, because why should she? Who cares? Some of the cast were really offended, like, 'She doesn't even know my name!' I'm like, 'Who cares? Madonna's doing our show. It doesn't matter.' "

" I had a lot of friends for a long time who were gay, and I didn't even realize it for awhile. Even in my mid- to late 20s, I was still pretty naive about it. "

" Nobody knows I sing. Even though I've done Broadway musicals. I would only pick it over acting because it's such a pure form of emotional expression. "

" I always thought, 'Oh, Cher seems so cool. If I ever met her, I know we'd be best friends.' "

" In terms of the first Christmas when I met everybody, I went over to Nick's grandfather's house where they were having the big Christmas dinner, and they have this tradition of this thing called oyster stew. "

" Karen will never die. Max Mutchnick, one of the creators of the show, has always maintained that Karen is a bat who balls up and hangs from a rafter and sleeps during the day and that she'll live forever. "

" Nobody knew if the pilot would even get picked up because it had two gay lead characters, which has never happened before. And now every show has at least two gay characters, if not many more. "

" We already do a couple numbers with chairs - chairs being a classic, Bob Fosse-ish, showbizzy prop, but the punk element is that it's just me and Stephanie and this funky band from Austin. "

" People get up and say, 'I didn't prepare a speech because I didn't think I would win.' Well, that's dumb. "

" Nick was cast first in both 'Smashed' and 'Kings.' "

" Nick hasn't seen me naked - I'm not a person who's constantly flinging my clothes aside and strutting about. "

" There were some articles written about our marriage, mythologising it, making it into the greatest love story ever told. "

" I had been watching the Emmys since I was probably 5 years old. Those shows, when you're a kid, it all seems like such a big, big deal, and only special certain people would win one of these big things like a Tony or an Emmy or an Oscar. "

" John Cleese was my personal favorite because he played my husband for a whole season - and Minnie Driver. We almost had our own, like, show all living in a house together. And Gene Wilder was just so dear. "

" People who have theater or sketch-comedy backgrounds seem to be more, you know, our speed. Like Amy Poehler and Will Arnett - we double date. "

" I lived in Chicago in the early '80s and did a ton of theater, and then Nick lived there in the '90s and did a ton of theater. Then we both moved to L.A. and did a ton of television. "

" He proposed, in London, in 2002. "

" I'll quit coffee. It won't be easy drinking my Bailey's straight, but I'll get used to it. It'll still be the best part of waking up. "

" Playing Karen was so satisfying that it almost cured my acting bug completely. Not that I had conquered the world of acting. It was just that I had something to prove to myself when I started Will & Grace. Now I feel like, okay, well, I've satisfied that. "

" Actors talking about themselves. Nothing better! "

" I've done three Broadway musicals and tons of concerts and all kinds of things, but nobody knows that except the people in New York. "

" A lot of people are saying it's an inspiration to see a couple who are in love and getting a kick out of each other. "

" I tend to let the chips fall where they may. I don't know if that's right or wrong. "

" I never had a burning desire to have children. But then I met Nick, and I thought, 'This is the only person I'd do this with.' So we tried, but I was a little long in the tooth for that sort of thing. But we didn't turn it into a soap opera. We tried for about a year or so, and it didn't happen and took that to mean it wasn't meant to be. "

" I think theater is more about living and breathing, versus TV, which can vary. "

" Nick has said he would divorce me if I got Botox. "