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" We had a gay marriage on 'Will & Grace' in 2000, 2001. And I was like, 'Gay marriage?' I mean, it was just really early. "

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" I get offered stuff that I don't really want to do, so hopefully, I'm just kind of waiting for the right thing. "

" I kind of connected the dots, like, 'Oh, we're just saying stuff. We're just saying things that make sense, so let's just say them like you say them in real life.' It was my first and one of my only acting lessons 'cause I never really studied acting. "

" Karen was always such a lawless rebel: carrying a gun in her purse, flirting with 14-year-old boys. She's the worst. You know that horrible guy Milo Yiannopoulos? She has about as many redeeming qualities as he has. "

" Nick hasn't seen me naked - I'm not a person who's constantly flinging my clothes aside and strutting about. "

" Karen will never die. Max Mutchnick, one of the creators of the show, has always maintained that Karen is a bat who balls up and hangs from a rafter and sleeps during the day and that she'll live forever. "

" I had been watching the Emmys since I was probably 5 years old. Those shows, when you're a kid, it all seems like such a big, big deal, and only special certain people would win one of these big things like a Tony or an Emmy or an Oscar. "

" People find it confusing I'm in a band, even though music was my main thing before acting. "

" Multi-camera's fun because you have the immediacy of the audience and just being able to tell the story more or less straight through. The thing I like about single-camera is that you have the luxury of shooting a lot of different options. "

" You can really shoot things you think might work on camera one way, then you can try it that way, and then if you think it could also work another way, you have that luxury of shooting a bunch of different steps, and then they can decide in editing what works the best. "

" I love Chicago - absolutely love Chicago. I mean, I'd much rather go to Chicago and do a play or a musical than New York, honestly. Because just probably for reasons that are obvious to you. It's just a little bit - it's a nicer, easier city. "

" I used to watch 'ER' a little bit when it was at its kind of apex. "

" I had a lot of friends for a long time who were gay, and I didn't even realize it for awhile. Even in my mid- to late 20s, I was still pretty naive about it. "

" Woody Harrelson played a long-term love interest of Debra Messing's; I think it was for a whole season. They almost cast Nick in that part. They almost had given to him. But at the eleventh hour, Jim Burrows put in a call to Woody, and he said he would do it. "

" Nick can get up on stage and just wing it, whereas I would have to be taken to a mental institution. "

" I tend to let the chips fall where they may. I don't know if that's right or wrong. "

" He is not like Ron Swanson at all because he's very emotional and vulnerable. He is all of the things that I guess Ron was really deep down. He's not a Libertarian, but he does like bacon and meat. "

" All the writers on our show went in and got in the bed and took a picture in Cher's bed, even though she was never in it. "

" I certainly have gay friends, but I don't remember thinking, 'Oh my God, I have this friend, and they're gay, and that's so cool.' I mean, I was very naive until I got to a certain age. "

" I get deep into the creative aspect, and Nick is the people person. "

" There's sacrificing for your art, and then there's just being dumb. "

" My mom is elderly, and she's not doing too well, and I've literally never told her about 'Childrens Hospital,' because I fear that if she ever sees it, it will be like the coup de grace. "

" Nobody knows I sing. Even though I've done Broadway musicals. I would only pick it over acting because it's such a pure form of emotional expression. "

" One year at the SAG Awards, somebody practically knocked me over, and it was Helen Mirren. She was like, 'Oh my God - is it really you? I'm your biggest fan.' I was like, 'Wait, aren't you supposed to be home reading Shakespeare or something?' "

" Nobody's ever kept their sitcom character going after the show's off the air. "

" I'm from Oklahoma, and Nick's from a small town in Illinois. "

" You can't really be super conservative and continue to keep your audience, but at least the audience that we attract comes with a certain level of naughtiness. "

" All I know is Karen is besties with Donny and Melania. "

" I've done three Broadway musicals and tons of concerts and all kinds of things, but nobody knows that except the people in New York. "

" If we're ever seen having a public spat in a coffee shop, I think the concept of romance will die. "

" During 'Will & Grace,' we had so many things we had to go to where you get all dolled up. It's like pulling teeth for me. "