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" People find it confusing I'm in a band, even though music was my main thing before acting. "

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" I always hear some couples can't work together, and I don't get that. We have the most fun when we're working together. "

" I tend to let the chips fall where they may. I don't know if that's right or wrong. "

" Playing Karen was so satisfying that it almost cured my acting bug completely. Not that I had conquered the world of acting. It was just that I had something to prove to myself when I started Will & Grace. Now I feel like, okay, well, I've satisfied that. "

" Karen was always such a lawless rebel: carrying a gun in her purse, flirting with 14-year-old boys. She's the worst. You know that horrible guy Milo Yiannopoulos? She has about as many redeeming qualities as he has. "

" People get up and say, 'I didn't prepare a speech because I didn't think I would win.' Well, that's dumb. "

" I've always been a late bloomer, so I never feel like, 'Oh, I'm gettin' older; I guess everything is gonna stop.' I'm the opposite: 'Oh, I'm just getting started.' "

" I love Chicago - absolutely love Chicago. I mean, I'd much rather go to Chicago and do a play or a musical than New York, honestly. Because just probably for reasons that are obvious to you. It's just a little bit - it's a nicer, easier city. "

" I'll quit coffee. It won't be easy drinking my Bailey's straight, but I'll get used to it. It'll still be the best part of waking up. "

" Nick hasn't seen me naked - I'm not a person who's constantly flinging my clothes aside and strutting about. "

" I'm a big hit with guards at security. They're the center of my fan base, the airport security guards. "

" There's sacrificing for your art, and then there's just being dumb. "

" It's funny when you follow your own sort of bliss, then other people tend to respond in kind, meaning audiences. It's really weird how that works, but it does seem to apply to 'Nancy & Beth' especially. "

" I kind of connected the dots, like, 'Oh, we're just saying stuff. We're just saying things that make sense, so let's just say them like you say them in real life.' It was my first and one of my only acting lessons 'cause I never really studied acting. "

" I can understand everybody associates me with Karen, but beyond that, I think after time passes and a few years go by, that sort of becomes a non-issue. That character is far - I mean really, all the characters I've played are pretty far away from what I'm really like. "

" You can really shoot things you think might work on camera one way, then you can try it that way, and then if you think it could also work another way, you have that luxury of shooting a bunch of different steps, and then they can decide in editing what works the best. "

" I love creating new characters that are whatever they are. "

" My mom is elderly, and she's not doing too well, and I've literally never told her about 'Childrens Hospital,' because I fear that if she ever sees it, it will be like the coup de grace. "

" Now, it's weird not to have gay characters on a show. "

" That's all you ever want - to do your job well enough that people on the other end are happy. "

" I like to work. I mean, part of it for me is that I was a struggling actor, could barely pay my rent, until I was almost 40. "

" Nobody's ever kept their sitcom character going after the show's off the air. "

" Madonna was very cool. I thought she was really nice, really present, and she worked really, really hard... She didn't necessarily know our real names in real-life, because why should she? Who cares? Some of the cast were really offended, like, 'She doesn't even know my name!' I'm like, 'Who cares? Madonna's doing our show. It doesn't matter.' "

" People who have theater or sketch-comedy backgrounds seem to be more, you know, our speed. Like Amy Poehler and Will Arnett - we double date. "

" I had a lot of friends for a long time who were gay, and I didn't even realize it for awhile. Even in my mid- to late 20s, I was still pretty naive about it. "

" Actors talking about themselves. Nothing better! "

" Woody Harrelson played a long-term love interest of Debra Messing's; I think it was for a whole season. They almost cast Nick in that part. They almost had given to him. But at the eleventh hour, Jim Burrows put in a call to Woody, and he said he would do it. "

" We had a gay marriage on 'Will & Grace' in 2000, 2001. And I was like, 'Gay marriage?' I mean, it was just really early. "

" I get offered stuff that I don't really want to do, so hopefully, I'm just kind of waiting for the right thing. "

" Isn't that sort of what happened with gay marriage? Right before gay marriage was legalized, everybody was just losing their minds and, like, the worst possible things were happening, and it was just all like it couldn't get any worse, and then it suddenly got a lot better. "

" Nobody knows I sing. Even though I've done Broadway musicals. I would only pick it over acting because it's such a pure form of emotional expression. "