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" I have a philosophy that has guided me throughout all of my scientific career, and that is, I think of myself as a fairly thoughtful person. I don't go into projects impetuously, and I try to select important problems. "

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" When I was a medical student in the 1950s, we practically never spoke about Alzheimer's disease. And why is that so? And that is because people didn't live long enough to have Alzheimer's disease. "

Eric Kandel

Enough

Long

Live

" Life is sort of a circle. You come back to a lot of the interests that you had early in life. "

" Indeed, artists, particularly modern artists, have intentionally limited the scope and vocabulary of their expression to convey, as Mark Rothko and Ad Reinhardt do, the most essential, even spiritual, ideas of their art. "

" Modernism in Vienna brought together science and culture in a new way to create an Age of Insight that emphasized a more complex view of the human mind than had ever existed before. "

" The brain is a complex biological organ possessing immense computational capability: it constructs our sensory experience, regulates our thoughts and emotions, and controls our actions. "

" What the Ellison Foundation and I are hoping to encourage is a more holistic approach to psychiatry, in which psychotherapy is put on as rigorous a level as psychopharmacology. "

" You learn emotional experiences as much as you learn cognitive experiences, except that they are more unconscious. Sometimes one represses the cognitive component of it, but it's often more difficult to repress the emotional component. "

Eric Kandel

Sometimes

Learn

" It may act as an ancillary factor, but by itself, the mutation in tau doesn't give you Alzheimer's disease. This is not to say the tau is not very important. It may be important in propagating the disorder from one cell to another. But as a causal mechanism, the evidence is strongest for beta amyloid abnormalities. "

" You could double the number of synaptic connections in a very simple neurocircuit as a result of experience and learning. The reason for that was that long-term memory alters the expression of genes in nerve cells, which is the cause of the growth of new synaptic connections. "

" I went to medical school after having decided to do so somewhere between my junior and senior year at Harvard - very late. I initially wanted to be an intellectual historian. "

" My parents genuinely loved Vienna, and in later years I learned from them why the city exerted a powerful hold on them and other Jews. My parents loved the dialect of Vienna, its cultural sophistication, and artistic values. "

" My heart beats in three-quarter time. "

" Since Socrates and Plato first speculated on the nature of the human mind, serious thinkers through the ages - from Aristotle to Descartes, from Aeschylus to Strindberg and Ingmar Bergman - have thought it wise to understand oneself and one's behavior. "

" My parents were not born in Vienna, but they had spent much of their lives there, having each come to the city at the beginning of World War I when they were still very young. "

" I've been around a long time, and I've been interested in memory for a long time. And one of my earlier interests in molecular biology of memory led me to define the switch that converts short term to long term memory. "

" I found working in the lab is so completely different than reading a textbook about it. You know, you're planning strategies; you're working with your own hands. There's essential satisfaction in running experiments. "

" I like problems at the borders of disciplines. One of the reasons that neurobiology of learning and memory appeal to me so much was that I liked the idea of bringing biology and psychology together. "

" The problem of psychoanalysis is not the body of theory that Freud left behind, but the fact that it never became a medical science. It never tried to test its ideas. "

" I was reluctant to be critical of the United States because I thought the United States could do no wrong; that the government could not lie to its people. "

" If you have a lesion in the hippocampus in both sides, you have short term memory, but you can convert that short term memory into long term memory. "

" I had many moments of disappointment, despondency, and exhaustion, but I always found that by reading the literature and showing up at my lab looking at the data as they emerged day by day and discussing them with my students and postdoctoral fellows, I would gain a notion of what to do next. "

" Ever since the Enlightenment, people thought that we were living in a rational universe. They thought that God was a mathematician and that the function of the scientist was to figure out the mathematical rules whereby the universe was created. "

" I was born in Vienna on November 7, 1929, eleven years after the multiethnic Austro-Hungarian Empire fell apart following its defeat in World War I. "

" One can, in principle, outline sort of a set of neural circuits that are critically involved and even identify disorders that affect different components of that neural circuit and see what happens if you knock out, for example, inability to recognize faces, how it affects your response to portraiture. "

" I've been collecting art for much of my adult life. I started around 1960. And my wife and I really enjoy art a great deal. We don't have a lot of money, so we have works on paper, but we enjoy them a great deal. "

" There was little in my early life to indicate that an interest in biology would become the passion of my academic career. In fact, there was little to suggest I would have an academic career. "

" I would not necessarily say that scientists and artists need to collaborate with one another, but it would be helpful for them to talk to one another to, perhaps, give rise to specific ideas that may or may not be carried out together. "

" Psychoanalysis has a degree of unreliability about it. You will never know whether you've found the truth. You may find a subjective truth, but you don't know. "

" Nerve cells communicate with one another at specialized points called synapses. And these synapses are plastic - they can be modified by learning. "

" Rather than studying the most complex form of memory in a very complicated animal, we had to take the most simple form - an implicit form of memory - in a very simple animal. So I began to look around for very simple animals. And I focused in on the marine snail Aplysia. "