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" I think something very simple that everybody can do is they can participate in medical research as subjects. Personal genome project, for example, will take on as many subjects as we can find. "

George M. Church

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Medical

Research

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" If we go into space, we need enhancements that handle radiation and osteoporosis... or else we're dead. So what seems like an enhancement in one generation becomes life and death in another generation. "

" Our ancestors didn't need any genetic enhancements to be able to sit for twelve hours a day and eat fatty, sugary foods, but we need enhancements that handle that altered environment. "

" At some point, someone will come up with an airtight argument as to why they should have a cloned child. At that point, cloning will be acceptable. "

" Most people are excited about themselves. Personal genome will deliver for inexpensively something about science to which you can relate. Just like computers are becoming something to which you can relate. It should be even easier to relate to your own biology, and I hope that will be one of the ways we get broader literacy in science. "

" Reversal is something that has been demonstrated in a number of different animals in a number of different ways. I think that's going to translate into larger animals and humans. We won't know until we try. But we are trying 65 different genes in different combinations to see if we can reproduce the aging reversal that we've seen in small animals. "

" There's this very interesting and complicated connection between our environment and our genes and the traits that come out of the environment plus genes. And there's huge potential. I mean we see amazing abilities. Marie Curie, Albert Einstein. All sorts of arts, and literature and so forth. These are not typical traits of everybody on earth. "

" Science has very definite faith components, and most religions don't stick to faith. They venture out into making predictions about our physical world. They don't just say there's something that is completely unconnected to us. They say actually it affects a lot. And when they do that, they merge. "

" If you get very fine, accurate, and inexpensive control over your genome, you can fundamentally change the kind of organism you are. You are extending human capacity. "

" There are a few genetic traits that make people feel sorry for you, and there are some, like narcolepsy, at which people take personal offense unless you tell them in advance. "

" I think my original inspiration came from just natural curiosity about science and math and biology. In particular, I would say that, as I matured, it became more a feeling of trying to avoid the waste that occurs in the world where we have 6.5 billion minds. If you're a computer scientist, you can think of them as supercomputers. "

" The rewards for biotechnology are tremendous - to solve disease, eliminate poverty, age gracefully. It sounds so much cooler than Facebook. "

" We went from a world where almost nobody knew anything about computers to a world where almost all of us are computer geeks for a huge fraction of our day. And I'd like to see that happen with the digital world of biological molecules, too. "

" Your genetics is not your destiny. "

" If you get a personal genome, you should be able to get personal cell lines, stem cell derived from your adult tissues, that allow you to bring together synthetic biology and the sequencing so that you can repair parts of your body as you age or repair things that were inherited disorders. "

" I'm a champion for personal differences. I have no sympathy for drug companies that can't figure out how to make personalized medicine. We could generalize that to 'All society should be much more personalized.' "

" Preventing ongoing extinction of elephants, rhinoceroses, and other threatened species is critically important. By all means, we must set priorities for allocating finite conservation resources. "

" Very often, as I wander through life, I'll get that old feeling that I've come back from the future, and I'm living in the past. And it's a really horrible feeling. "

" A few dozen changes to the genome of a modern elephant - to give it subcutaneous fat, woolly hair and sebaceous glands - might suffice to create a variation that is functionally similar to the mammoth. Returning this keystone species to the tundras could stave off some effects of warming. "

" You can't just hoard your ideas inside the ivory tower. You have to get them out into the world. "

" The one thing that is bad for society is low diversity. If you become a monoculture, you are at great risk of perishing. Therefore, the recreation of Neanderthals would be mainly a question of societal risk avoidance. "

" I am 3.8 percent Neanderthal. One of my ancestors mated with a Neanderthal, and I am not embarrassed by that. "

" We will have to make a decision, as we go into new environments outside of earth, whether we want to drag along with us all our pathogens. We can, or we can't - it's up to us - but I consider that part of genome engineering is how we interact with the huge part of our genome which is our microbiome. "

" Letting the tundra melt is the equivalent to burning all of the forests in all of the world and their roots two and a half times over. "

" Trees are essentially growing chairs. There are lots of primates that sit and sleep in them. "

" What I really wanted was for everybody to have their genome and, ideally, everybody to share their genome, and for that, we needed to bring the price way down. "

George M. Church

Down

Genome

" I have a rule against saying something is impossible unless it violates laws of physics. "

" I would argue that we're not limited by actual DNA. You can re-create the ancient DNA by looking at the genomes of existing animals. "

" It sounds a little bit too arrogant, but I think I certainly have a working model for how I conduct my life, and it may or may not be a correct worldview. "

" I will make the argument that we are poorly adapted to our current environment. I mean, we did not evolve to sit all day and be exposed to giant amounts of really tasty food. "