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" It alarms me to think of all that I have read and how little of it has stayed with me. "

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" I think actors are attracted to the idea of other identities and concealing themselves behind some other identity. "

" I'm reasonably easygoing. Messing up my lines or making a fool of myself is where you find my fears. Like a lot of English people, I'm prey to embarrassment - the dread that everyone's sort of sniggering at you, that you're going to look like an idiot. I think that sort of halts us all. "

" I have my moments. Ever since I was a boy, I never was someone who was at ease with happiness. Too often I embrace introspection and self-doubt. I wish I could embrace the good things. "

" Believe it or not, perhaps I don't show it much, or well, but I think I like people. "

" Seems to me that this business, for actors anyway, is not so much about whether or not you do good work. It's about whether or not you get the chance to do good work. "

" I never was someone who was at ease with happiness. "

" My dad gave me my first bike at 16. I soon fell off and was in a wheelchair for weeks. I haven't fallen since. "

" Unhappiness is an unfinished state; happy people don't need our help. "

" L.A. runs on optimism, enthusiasm and flattery. I think you can go a little bit crazy. I've heard people say there's a limit to the number of years you can stay in this city without going slightly mad. It's just too damn sunny in every dimension - weather-wise, socially and professionally. "

" I didn't realize House would be the central character, more the bitter comic relief appearing occasionally. I relish his wounded nature - the lameness, the scarred Byronic hero. "

" I think there is a basic comfort in clever people who know things. "

" Humility was considered a great virtue in my family household. No show of complacency or self-satisfaction was ever tolerated. Patting yourself on the back was definitely not encouraged, and pleasure or pride would be punishable by death. "

" I admit I can't shake the idea that there is virtue in suffering, that there is a sort of psychic economy, whereby if you embrace success, happiness and comfort, these things have to be paid for. "

" I get anxious about a lot of things, that's the trouble. I get anxious about everything. I just can't stop thinking about things all the time. And here's the really destructive part - it's always retrospective. I waste time thinking of what I should have said or done. "

" I feel like I'm working on an oil rig right now. I'm away from home a lot. "

" I wouldn't be able to act like Al Pacino or play the piano like Dr. John, But I could probably act better than Dr. John and play the piano better than Al Pacino. "

" Muddy Waters, I suppose, was my first great hero. You know, every boy wants to be a guitar player, and Muddy Waters was just the king. He was the King Bee. He was it. "

" I don't like the act of talking; it makes me slightly light-headed. "

" I feel like a hostage to fortune. Not that I am complaining. I wanted to play the role. But in truth I didn't think the show would be such a success. OK, I thought it would fail. Not because it was bad. I was confident it was good, but plenty of good things just sort of wither on the vine. "

" I think pain is a very - it's an extremely hard thing to empathize moment to moment. And you often don't remember your own pain, you know, that moment that you broke a limb or you burned yourself or, I think, this is a common thing that women talk about with childbirth, that the memory of the pain is hard to summon up and relive, thankfully. "

" I have always stuck up for Western medicine. You can chew all the celery you want, but without antibiotics, three quarters of us would not be here. "

" Lots of people would say House doesn't have any charm at all. I would disagree, though: I find him immensely charming and endlessly entertaining. He has a sort of grace and a wit about him, and ultimately, I think he is on the side of the angels. "

" I run six-to-eight miles a day, plus weights and aerobics in the lunch hour. I also lie a lot, which keeps me thin. "

" I've never been clever with money. I will buy anything at the top of the market. "

" I think my father gave me a great reverence for medical science. He was about as opposite to the personality of House as one could imagine. He was polite and easygoing, and would have gone to great lengths to make his patients feel attended to and heard and sympathized with. "

" Pain is an event. It happens to you, and you deal with it in whatever way you can. "

" Screenwriting is the most prized of all the cinematic arts. Actually, it isn't, but it should be. "

" I am a coffee fanatic. Once you go to proper coffee, you can't go back. You cannot go back. "

" I think maybe even one of the reasons I became an actor was actually to hide. I mean, it sounds paradoxical because, of course, people are standing up in a public place and encouraging other people to look at them. So that's not the conventional definition of hiding. "

" It's easier for a camel to pass through the eye of a needle than for a rich man to make a blues record. "