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" When something like personal genomics or synthetic biology suddenly appears - it seems to suddenly appear - we might have been working on it for 30 years, but it seems to come out of nowhere. Then you need strategies for engaging a lot of people and thinking about where it will be going in the next few months or few years. "

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" In my lab, we are constantly asking, 'What's the utility of this pure science that we're doing? Let's nudge it a little bit in a direction where people can connect to it and have some fun and/or help some very serious problems they have.' "

George M. Church

Fun

Help

People

" The best way to predict the future is to change it. "

" I don't actually believe there's any such thing as privacy. "

" If we go into space, we need enhancements that handle radiation and osteoporosis... or else we're dead. So what seems like an enhancement in one generation becomes life and death in another generation. "

" We have a love affair with the idea of the 'natural,' even though we, as a species, are about as unnatural as you can imagine. "

" What I really wanted was for everybody to have their genome and, ideally, everybody to share their genome, and for that, we needed to bring the price way down. "

George M. Church

Down

Genome

" Terrorism is not a public health threat, relative to cancer and heart disease and malaria and so forth. "

" I'll drop something for a while, a year or maybe several years, and then pick it up again. I think that's the way successful innovators work. They keep juggling ideas, keeping them in the air, in the back of their mind, to inspire them or enable new recombinations. "

" Aside from bringing back extinct species, reanimation could help living ones by restoring lost genetic diversity. The Tasmanian devil (aka Sarcophilus harrisii) is so inbred at this point that most species members can exchange tumor cells without rejection. "

" I am 3.8 percent Neanderthal. One of my ancestors mated with a Neanderthal, and I am not embarrassed by that. "

" We know that there is a connection between our feelings and our brain. "

" Someone younger at heart should replace you, and that should be you. I'm willing to. I'm willing to become younger. I try to reinvent myself every few years anyway. "

" If you get very fine, accurate, and inexpensive control over your genome, you can fundamentally change the kind of organism you are. You are extending human capacity. "

" You should have personalized genomics, personalized physiology, personalized medicine, where each person's different, and each body is an integrated whole. "

" We might want to figure out what are the positive effects of autism - mild cases. "

" Letting the tundra melt is the equivalent to burning all of the forests in all of the world and their roots two and a half times over. "

" As part of our dedication to safety engineering in biology, we're trying to get better at creating physically contained test systems to develop something that eventually will be so biologically contained that we won't need physical containment anymore. "

" We have the ability to completely change our environment to go... to take on... to inherit, in a certain sense, things far beyond our DNA, and that's inheritable. And we can see evolution in action as our ideas evolve and undergo a kind of Darwinian selection not at the DNA level. And we can go off into space. "

" We will have to make a decision, as we go into new environments outside of earth, whether we want to drag along with us all our pathogens. We can, or we can't - it's up to us - but I consider that part of genome engineering is how we interact with the huge part of our genome which is our microbiome. "

" I don't think it is about stalling or curing: it's about reversing. Curing gives you the impression of immortality. Stalling gives you the impression that you'll be 85 forever, which is not great. "

" Very often, as I wander through life, I'll get that old feeling that I've come back from the future, and I'm living in the past. And it's a really horrible feeling. "

" If society becomes comfortable with cloning and sees value in true human diversity, then the whole Neanderthal creature itself could be cloned by a surrogate mother chimp - or by an extremely adventurous female human. "

" Reversal is something that has been demonstrated in a number of different animals in a number of different ways. I think that's going to translate into larger animals and humans. We won't know until we try. But we are trying 65 different genes in different combinations to see if we can reproduce the aging reversal that we've seen in small animals. "

" If you get a personal genome, you should be able to get personal cell lines, stem cell derived from your adult tissues, that allow you to bring together synthetic biology and the sequencing so that you can repair parts of your body as you age or repair things that were inherited disorders. "

" Your genetics is not your destiny. "

" Every cell in our body, whether it's a bacterial cell or a human cell, has a genome. You can extract that genome - it's kind of like a linear tape - and you can read it by a variety of methods. Similarly, like a string of letters that you can read, you can also change it. You can write, you can edit it, and then you can put it back in the cell. "

" Most groups patent ways of using genetic discoveries as part of non-obvious diagnostic and therapeutic protocols and slightly or greatly altered genes. "

" How do you get things out of your head, out of your lab, and into the world? If you're not part of the economic community, there's a chance... you'll fall behind. "

" I will make the argument that we are poorly adapted to our current environment. I mean, we did not evolve to sit all day and be exposed to giant amounts of really tasty food. "

" I think my original inspiration came from just natural curiosity about science and math and biology. In particular, I would say that, as I matured, it became more a feeling of trying to avoid the waste that occurs in the world where we have 6.5 billion minds. If you're a computer scientist, you can think of them as supercomputers. "