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" You can open up a centenarian's brain, and you'll see some areas that look like that of a 50-year-old or of a 110-year-old. You can have variation in the basic process of aging, called senescence, in different parts of the same body. "

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" Growing new limbs, copying internal organs like a Xerox machine, exponential increases in computing power, better eyes and ears - I could read stories like this endlessly. "

S. Jay Olshansky

New

Better

" The reason we have cancer and heart disease is the same reason you can't get rid of the wear and tear on your tires on your car: as soon as you use them, you are wearing them away. You can't make eternal tires, and it's the same with the human body. "

" The last thing you ever want to do is extend the period of frailty and disability and make people unhealthy for a longer time period. So lifespan extension in and of itself should not be the goal of medicine, nor should it be the goal of public health, nor should it be the goal of aging science. "

" The only control we have over the duration of our life is to shorten it, and we do that all the time. "

" The way that we are going after ageing, I think, is a problem. The modern medical model is basically designed to attack one disease at a time. Independent of all other diseases and independent of the basic process of ageing itself. "

" I don't have a fear of aging or a fear of death. "

" In centenarians and supercentenarians - people over 110 - you see a higher level of fecundity much later in life. "

" The vast majority of studies say anti-aging supplements don't work. "

" Someone will eventually succeed in this hunt for a longevity pill, and when they do, one of the greatest advances in the history of medicine will have been achieved. "

" I have little doubt that gerontologists will eventually find a way to avoid, or more likely, delay, the unpleasantries of extended life. "

" The real problem is that there's a tendency to associate ageing with loss and decline and things that aren't desirable. But experiencing all that there is to experience in life - whether that's at the age of ten or thirty or fifty or eighty - is what life is all about. "

" A lifetime of low calories has come naturally to the longest-lived people in the world... in the Japanese archipelago of Okinawa. "

" The field of ageing research is full of characters. We have hucksters claiming that cures for ageing can be bought and sold; prophetic seers, their hands extended for money, warning that immortality is nigh; and would-be Nobelists working methodically in laboratories in search of a pill to slow ageing. "

S. Jay Olshansky

Research

Slow

" If you can slow the biological process of aging, even a minor slowdown in the rate at which we age yields improvements in virtually every condition of frailty and disability and mortality that we see at later ages. "

" In the developed world, we live 30 years longer, on average, than our ancestors born a century ago, but the price we pay for those added years is the rise of chronic diseases. "

" I'm not sure the least educated members of the population are missing out on the advances in medical technology as much as they are adopting harmful behavioral habits that shorten their life. "

" As soon as a handful of scientists come up with an intervention shown to influence aging in other species, they begin selling it as an intervention for humans, even though there may not be evidence it works. "

" Find a way to get a full-body massage every day. "

" The modern rise of Alzheimer's Disease in the twentieth century is not a sign of failure. It's a sign of success. Success in living long enough to see that disease expressed. "

" There is a possibility that there is somebody out there alive today over 122, but we'll probably never know it, because in all likelihood they come from either China or India, and they don't have reliable birth records. "

" Death is a zero sum game for which there is no cure. "

" Do we really want to continue to push out the envelope of survival only to see other things crop up that we may not like? "

" Physical immortality is seductive. The ancient Hindus sought it; the Greek physician Galen from the 2nd Century A.D. and the Arabic philosopher/physician Avicenna from the 11th Century A.D. believed in it. "

" The fact is that nothing in gerontology even comes close to fulfilling the promise of dramatically extended lifespan, in spite of bold claims to the contrary that by now should sound familiar. "

" Lifespan extension has never really been a goal of aging science, nor should it. "

" If you do an autopsy on an 85-year-old who died of a stroke, you will find five other things that person was about to die from. "

" Our concepts of aging really should be blurring because there are plenty of people who make it to older ages who aren't really any different in many ways than people who are decades younger. "

" When you hit your 40s, you begin to take notice of the effects of aging because people that you know begin to die of heart attacks and tumors, so we take notice of the effects of aging. "

" What we know for sure from our work and from others' is that mice have a life span of 1,000 days, dogs have 5,000 days, and we humans have 29,000 days. Recognizing that the duration is limited, and aging is inevitable, focus the attention on enhancing the quality of the days you have. "

" The evolutionary theory of senescence can be stated as follows: while bodies are not designed to fail, neither are they designed for extended operation. "