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" The evolutionary theory of senescence can be stated as follows: while bodies are not designed to fail, neither are they designed for extended operation. "
S. Jay Olshansky
While
Theory
Operation
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" We're not trying to make us live forever; we're not trying to even make us live significantly longer. What we're trying to do is extend the period of healthy life. "
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" The bodies we have are not made for extended use. We must cope with accumulated DNA damage, cell damage, muscle atrophy, bone loss, decreased muscle mass, and joints worn out from overuse during a lifetime of bipedal locomotion. It might have worked great for prehistoric humans, but it wreaks havoc on our knees and hips. "
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" Someone will eventually succeed in this hunt for a longevity pill, and when they do, one of the greatest advances in the history of medicine will have been achieved. "
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" Humans will die like all living things do, but we have the added burden of knowing that we will. "
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" The real problem is that there's a tendency to associate ageing with loss and decline and things that aren't desirable. But experiencing all that there is to experience in life - whether that's at the age of ten or thirty or fifty or eighty - is what life is all about. "
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" In centenarians and supercentenarians - people over 110 - you see a higher level of fecundity much later in life. "
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" You can open up a centenarian's brain, and you'll see some areas that look like that of a 50-year-old or of a 110-year-old. You can have variation in the basic process of aging, called senescence, in different parts of the same body. "
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" As soon as a handful of scientists come up with an intervention shown to influence aging in other species, they begin selling it as an intervention for humans, even though there may not be evidence it works. "
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" Death is a zero sum game for which there is no cure. "
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" The modern rise of Alzheimer's Disease in the twentieth century is not a sign of failure. It's a sign of success. Success in living long enough to see that disease expressed. "
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" Lifespan extension has never really been a goal of aging science, nor should it. "
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" A lot of people are living in a dream world - they want to deny that aging occurs or believe it doesn't have to occur. They'll hold on to this belief until the moment they die. The reality will eventually hit them. "
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" The fact is that nothing in gerontology even comes close to fulfilling the promise of dramatically extended lifespan, in spite of bold claims to the contrary that by now should sound familiar. "
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" The reason we have cancer and heart disease is the same reason you can't get rid of the wear and tear on your tires on your car: as soon as you use them, you are wearing them away. You can't make eternal tires, and it's the same with the human body. "
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" I have little doubt that gerontologists will eventually find a way to avoid, or more likely, delay, the unpleasantries of extended life. "
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" We know in the field of aging that some people tend to senesce, or grow older, more rapidly than others, and some more slowly. "
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" If you can slow the biological process of aging, even a minor slowdown in the rate at which we age yields improvements in virtually every condition of frailty and disability and mortality that we see at later ages. "
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" How long you live is less important than how healthy you are along the way. "
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" Exercise is roughly the only equivalent of a fountain of youth that exists today, and it's free to everyone. "
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" The field of ageing research is full of characters. We have hucksters claiming that cures for ageing can be bought and sold; prophetic seers, their hands extended for money, warning that immortality is nigh; and would-be Nobelists working methodically in laboratories in search of a pill to slow ageing. "
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" In the developed world, we live 30 years longer, on average, than our ancestors born a century ago, but the price we pay for those added years is the rise of chronic diseases. "
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" Find a way to get a full-body massage every day. "
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" The Faustian trade of the 20th century was, we got 30 years of additional life, but in return we got heart disease, cancer, stroke, Alzheimer's and sensory impairments. The question is: What Faustian trade are we making now, as we go after heart disease, cancer, stroke and Alzheimer's? "
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" When you hit your 40s, you begin to take notice of the effects of aging because people that you know begin to die of heart attacks and tumors, so we take notice of the effects of aging. "
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" Just because someone looks old doesn't mean he or she is. The skin of some people who spend a lot of time outdoors seems to age very rapidly. Someone can look 80 or 90 and only be 40 to 50. "
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" Fixing obesity is going to require a change in our modern relationship with food. I'm hopeful that we begin to see a turnaround in this childhood obesity epidemic. "
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" Ageing is very rare. We only see it in humans and laboratory animals and in zoo animals and in our pets. Basically, organisms that are protected from the external world. Once you create that protection, you live long enough to see ageing. "
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" If we do everything right, the best we can do is live out our potential with as little age-related disease and disability as possible. "
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" Older people may have always existed throughout history, but they were rare. "
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